業績

2017 原著論文
Comprehensive Analysis of Adverse Events Associated With Per Oral Endoscopic Myotomy in 1826 Patients: An International Multicenter Study. Haito-Chavez Y, Inoue H, Beard KW, Draganov PV, Ujiki M, Rahden BHA, Desai PN, Pioche M, Hayee B, Haji A, Saxena P, Reavis K, Onimaru M, Balassone V, Nakamura J, Hata Y, Yang D, Pannu D, Abbas A, Perbtani YB, Patel LY, Filser J, Roman S, Rivory J, Mion F, Ponchon T, Perretta S, Wong V, Maselli R, Ngamruengphong S, Chen YI, Bukhari M, Hajiyeva G, Ismail A, Pieratti R, Kumbhari V, Galdos-Cardenas G, Repici A, Khashab MA. Am J Gastroenterol. 2017 May 23. doi: 10.1038/ajg.2017.139. [Epub ahead of print] PMID: 28534521

Accuracy of diagnosing invasive colorectal cancer using computer-aided endocytoscopy. Takeda K, Kudo SE, Mori Y, Misawa M, Kudo T, Wakamura K, Katagiri A, Baba T, Hidaka E, Ishida F, Inoue H, Oda M, Mori K. Endoscopy. 2017 May 4. doi: 10.1055/s-0043-105486. [Epub ahead of print] PMID: 28472832

Prediction of the invasion depth of superficial squamous cell carcinoma based on microvessel morphology: magnifying endoscopic classification of the Japan Esophageal Society. Oyama T, Inoue H, Arima M, Momma K, Omori T, Ishihara R, Hirasawa D, Takeuchi M, Tomori A, Goda K. Esophagus. 2017;14(2):105-112. doi: 10.1007/s10388-016-0527-7. Epub 2016 Apr 6. PMID: 28386209 Free PMC Article

Accuracy of computer-aided diagnosis based on narrow-band imaging endocytoscopy for diagnosing colorectal lesions: comparison with experts. Misawa M, Kudo SE, Mori Y, Takeda K, Maeda Y, Kataoka S, Nakamura H, Kudo T, Wakamura K, Hayashi T, Katagiri A, Baba T, Ishida F, Inoue H, Nimura Y, Oda M, Mori K. Int J Comput Assist Radiol Surg. 2017 May;12(5):757-766. doi: 10.1007/s11548-017-1542-4. Epub 2017 Feb 28. PMID: 28247214

An international multicenter study evaluating the clinical efficacy and safety of per-oral endoscopic myotomy in octogenarians. Chen YI, Inoue H, Ujiki M, Draganov PV, Colavita P, Mion F, Romanelli J, Chiu P, Balassone V, Patel L, Abbas A, Yang D, Dunst C, Pioche M, Roman S, Rivory J, Ponchon T, Desilets D, Maselli R, Onimaru M, Nakamura J, Hata Y, Hajiyeva G, Ismail A, Ngamruengphong S, Bukhari M, Chavez YH, Kumbhari V, Repici A, Khashab MA. Gastrointest Endosc. 2017 Feb 21. pii: S0016-5107(17)30109-8. doi: 10.1016/j.gie.2017.02.007. [Epub ahead of print] PMID: 28235595

Efficacy and Safety of Peroral Endoscopic Myotomy for Treatment of Achalasia After Failed Heller Myotomy. Ngamruengphong S, Inoue H, Ujiki MB, Patel LY, Bapaye A, Desai PN, Dorwat S, Nakamura J, Hata Y, Balassone V, Onimaru M, Ponchon T, Pioche M, Roman S, Rivory J, Mion F, Garros A, Draganov PV, Perbtani Y, Abbas A, Pannu D, Yang D, Perretta S, Romanelli J, Desilets D, Hayee B, Haji A, Hajiyeva G, Ismail A, Chen YI, Bukhari M, Haito-Chavez Y, Kumbhari V, Saxena P, Talbot M, Chiu PW, Yip HC, Wong VW, Hernaez R, Maselli R, Repici A, Khashab MA. Clin Gastroenterol Hepatol. 2017 Feb 9. pii: S1542-3565(17)30144-1. doi: 10.1016/j.cgh.2017.01.031. [Epub ahead of print] PMID: 28189695

Current status of achalasia management: a review on diagnosis and treatment. Tuason J, Inoue H. J Gastroenterol. 2017 Apr;52(4):401-406. doi: 10.1007/s00535-017-1314-5. Epub 2017 Feb 10. Review. PMID: 28188367

Peroral endoscopic myotomy: a literature review and the first UK case series. Gulati S, Emmanuel A, Inoue H, Hayee B, Haji A. Clin Med (Lond). 2017 Feb;17(1):22-28. doi: 10.7861/clinmedicine.17-1-22. PMID: 28148574


2016 原著論文
Change in number and size of circulating tumor cells with high telomerase activity during treatment of patients with gastric cancer. Ito H, Yamaguchi N, Onimaru M, Kimura S, Ohmori T, Ishikawa F, Sato J, Ito S, Inoue H. Oncol Lett. 2016 Dec;12(6):4720-4726. doi: 10.3892/ol.2016.5239. Epub 2016 Oct 11. PMID: 28105179 Free PMC Article

Long-term prognostic impact of circulating tumour cells in gastric cancer patients. Ito H, Sato J, Tsujino Y, Yamaguchi N, Kimura S, Gohda K, Murakami K, Onimaru M, Ohmori T, Ishikawa F, Inoue H. World J Gastroenterol. 2016 Dec 14;22(46):10232-10241. doi: 10.3748/wjg.v22.i46.10232. PMID: 28028372 Free PMC Article

Evaluation of microvascular findings of deeply invasive colorectal cancer by endocytoscopy with narrow-band imaging. Nakamura H, Kudo SE, Misawa M, Kataoka S, Wakamura K, Hayashi T, Kudo T, Mori Y, Takeda K, Ichimasa K, Miyachi H, Katagiri A, Ishida F, Inoue H. Endosc Int Open. 2016 Dec;4(12):E1280-E1285. Epub 2016 Nov 10. PMID: 27995189 Free PMC Article

Microvasculature of the esophagus and gastroesophageal junction: Lesson learned from submucosal endoscopy. Maselli R, Inoue H, Ikeda H, Onimaru M, Yoshida A, Santi EG, Sato H, Hayee B, Kudo SE. World J Gastrointest Endosc. 2016 Nov 16;8(19):690-696. Review. PMID: 27909548 Free PMC Article

Classification of nuclear morphology in endocytoscopy of colorectal neoplasms. Kudo T, Kudo SE, Mori Y, Wakamura K, Misawa M, Hayashi T, Miyachi H, Katagiri A, Ishida F, Inoue H. Gastrointest Endosc. 2017 Mar;85(3):628-638. doi: 10.1016/j.gie.2016.10.039. Epub 2016 Nov 19. PMID: 27876633

Is POEM the Answer for Management of Spastic Esophageal Disorders? A Systematic Review and Meta-Analysis. Khan MA, Kumbhari V, Ngamruengphong S, Ismail A, Chen YI, Chavez YH, Bukhari M, Nollan R, Ismail MK, Onimaru M, Balassone V, Sharata A, Swanstrom L, Inoue H, Repici A, Khashab MA. Dig Dis Sci. 2017 Jan;62(1):35-44. doi: 10.1007/s10620-016-4373-1. Epub 2016 Nov 17. Review. PMID: 27858325

From POEM to POET: Applications and perspectives for submucosal tunnel endoscopy. Chiu PW, Inoue H, Rösch T. Endoscopy. 2016 Dec;48(12):1134-1142. Epub 2016 Nov 17. PMID: 27855465

Long-term outcome of peroral endoscopic myotomy for achalasia treatment in a 9-year-old female patient. Yamashita K, Shiwaku H, Hirose R, Kai H, Nakashima R, Kato D, Beppu R, Takeno S, Sasaki T, Nimura S, Iwasaki A, Inoue H, Yamashita Y. Asian J Endosc Surg. 2016 Nov;9(4):332-335. doi: 10.1111/ases.12296. Epub 2016 May 18. PMID: 27188526

Peroral endoscopic myotomy for esophageal achalasia: outcomes of the first over 100 patients with short-term follow-up. Shiwaku H, Inoue H, Yamashita K, Ohmiya T, Beppu R, Nakashima R, Takeno S, Sasaki T, Nimura S, Yamashita Y. Surg Endosc. 2016 Nov;30(11):4817-4826. Epub 2016 Mar 1. PMID: 26932548

A multicenter international registry of redo per-oral endoscopic myotomy (POEM) after failed POEM. Tyberg A, Seewald S, Sharaiha RZ, Martinez G, Desai AP, Kumta NA, Lambroza A, Sethi A, Reavis KM, DeRoche K, Gaidhane M, Talbot M, Saxena P, Zamarripa F, Barret M, Eleftheriadis N, Balassone V, Inoue H, Kahaleh M. Gastrointest Endosc. 2017 Jun;85(6):1208-1211. doi: 10.1016/j.gie.2016.10.015. Epub 2016 Oct 15. PMID: 27756611

Long-term outcomes of per-oral endoscopic myotomy in patients with achalasia with a minimum follow-up of 2 years: an international multicenter study. Ngamruengphong S, Inoue H, Chiu PW, Yip HC, Bapaye A, Ujiki M, Patel L, Desai PN, Hayee B, Haji A, Wong VW, Perretta S, Dorwat S, Pioche M, Roman S, Rivory J, Mion F, Ponchon T, Garros A, Nakamura J, Hata Y, Balassone V, Onimaru M, Hajiyeva G, Ismail A, Chen YI, Bukhari M, Haito-Chavez Y, Kumbhari V, Maselli R, Repici A, Khashab MA. Gastrointest Endosc. 2017 May;85(5):927-933.e2. doi: 10.1016/j.gie.2016.09.017. Epub 2016 Sep 20. PMID: 27663714

Response. Bechara R, Onimaru M, Ikeda H, Inoue H. Gastrointest Endosc. 2016 Oct;84(4):752-3. doi: 10.1016/j.gie.2016.05.039. No abstract available. PMID: 27633366

Comparison of the endocytoscopic and clinicopathologic features of colorectal neoplasms. Takeda K, Kudo SE, Misawa M, Mori Y, Kudo T, Kodama K, Wakamura K, Miyachi H, Hidaka E, Ishida F, Inoue H. Endosc Int Open. 2016 Apr;4(4):E397-402. doi: 10.1055/s-0042-101753. Epub 2016 Mar 24. PMID: 27547815 Free PMC Article

Impact of an automated system for endocytoscopic diagnosis of small colorectal lesions: an international web-based study. Mori Y, Kudo SE, Chiu PW, Singh R, Misawa M, Wakamura K, Kudo T, Hayashi T, Katagiri A, Miyachi H, Ishida F, Maeda Y, Inoue H, Nimura Y, Oda M, Mori K. Endoscopy. 2016 Dec;48(12):1110-1118. Epub 2016 Aug 5. PMID: 27494455

[Minimally Invasive Treatment of Esophageal Benign Diseases]. Inoue H. Kyobu Geka. 2016 Jul;69(8):705-12. Japanese. PMID: 27440038

[A Case of HER2-Positive Esophagogastric Junction Cancer with Perforation Curatively Resected after Neoadjuvant Chemotherapy plus Trastuzumab]. Toshima H, Hisamatsu A, Shimada K, Saito M, Suzuki M, Matsukawa M, Inoue H. Gan To Kagaku Ryoho. 2016 Jun;43(6):761-4. Japanese. PMID: 27306816

Peroral endoscopic myotomy for Jackhammer esophagus: to cut or not to cut the lower esophageal sphincter. Bechara R, Ikeda H, Inoue H. Endosc Int Open. 2016 May;4(5):E585-8. doi: 10.1055/s-0042-105204. Epub 2016 Apr 8. PMID: 27274539 Free PMC Article

Per Oral Endoscopic Myotomy for Achalasia: A Detailed Description of the Technique and Review of the Literature. Grimes KL, Inoue H. Thorac Surg Clin. 2016 May;26(2):147-62. doi: 10.1016/j.thorsurg.2015.12.003. Epub 2016 Feb 10. Review. PMID: 27112254

Characterization of Colorectal Lesions Using a Computer-Aided Diagnostic System for Narrow-Band Imaging Endocytoscopy. Misawa M, Kudo SE, Mori Y, Nakamura H, Kataoka S, Maeda Y, Kudo T, Hayashi T, Wakamura K, Miyachi H, Katagiri A, Baba T, Ishida F, Inoue H, Nimura Y, Mori K. Gastroenterology. 2016 Jun;150(7):1531-1532.e3. doi: 10.1053/j.gastro.2016.04.004. Epub 2016 Apr 9. No abstract available. PMID: 27072671 Free Article

POEM, the Prototypical "New NOTES" Procedure and First Successful NOTES Procedure. Bechara R, Inoue H. Gastrointest Endosc Clin N Am. 2016 Apr;26(2):237-55. doi: 10.1016/j.giec.2015.12.002. Review. PMID: 27036895

Per-oral endoscopic myotomy, 1000 cases later: pearls, pitfalls, and practical considerations. Bechara R, Onimaru M, Ikeda H, Inoue H. Gastrointest Endosc. 2016 Aug;84(2):330-8. doi: 10.1016/j.gie.2016.03.1469. Epub 2016 Mar 26. Review. PMID: 27020899

Adjustable countertraction during endoscopic submucosal dissection of a large, fundus-body, laterally spreading tumor. Balassone V, Ikeda H, Sumi K, Inoue H. Gastrointest Endosc. 2016 Sep;84(3):524-5. doi: 10.1016/j.gie.2016.03.1476. Epub 2016 Mar 26. No abstract available. PMID: 27020895

New endoscopic classification of the cardiac orifice in esophageal achalasia: Champagne glass sign. Gomi K, Inoue H, Ikeda H, Bechara R, Sato C, Ito H, Onimaru M, Kitamura Y, Suzuki M, Nakamura J, Hata Y, Maruyama S, Sumi K, Takahashi H. Dig Endosc. 2016 Sep;28(6):645-9. doi: 10.1111/den.12642. Epub 2016 Apr 21. PMID: 26969481

Magnifying chromoendoscopic and endocytoscopic findings of juvenile polyps in the colon and rectum. Takeda K, Kudo SE, Mori Y, Misawa M, Kudo T, Wakamura K, Hayashi T, Miyachi H, Ishida F, Inoue H. Oncol Lett. 2016 Jan;11(1):237-242. Epub 2015 Nov 10. PMID: 26870195 Free PMC Article

Submucosal tunnel endoscopy: Peroral endoscopic myotomy and peroral endoscopic tumor resection. Eleftheriadis N, Inoue H, Ikeda H, Onimaru M, Maselli R, Santi G. World J Gastrointest Endosc. 2016 Jan 25;8(2):86-103. doi: 10.4253/wjge.v8.i2.86. Review. PMID: 26839649 Free PMC Article

Peroral endoscopic myotomy: first human experience with a water-jet-assisted triangle knife. Balassone V, Sumi K, Inoue H. Gastrointest Endosc. 2016 Jun;83(6):1279. doi: 10.1016/j.gie.2015.12.031. Epub 2016 Jan 6. No abstract available. PMID: 26772890

Histological findings of divided muscle after peroral endoscopic myotomy. Shiwaku H, Inoue H, Nimura S, Yamashita K, Ohmiya T, Takeno S, Sasaki T, Yamashita Y. Ann Gastroenterol. 2016 Jan-Mar;29(1):94-5. PMID: 26752956 Free PMC Article

Diagnosis of sessile serrated adenomas/polyps using endocytoscopy (with videos). Mori Y, Kudo SE, Ogawa Y, Wakamura K, Kudo T, Misawa M, Hayashi T, Katagiri A, Miyachi H, Inoue H, Oka S, Matsuda T. Dig Endosc. 2016 Apr;28 Suppl 1:43-8. doi: 10.1111/den.12601. Review. PMID: 26748690

Peroral endoscopic myotomy for achalasia after distal gastrectomy. Tanaka S, Kawara F, Inoue H, Kurosawa M, Toyonaga T, Azuma T. Endoscopy. 2015;47 Suppl 1 UCTN:E511-2. doi: 10.1055/s-0034-1393229. Epub 2015 Oct 22. No abstract available. PMID: 26492300

Peroral endoscopic tumor resection for an esophageal bronchogenic cyst. Bechara R, Onimaru M, Kushima M, Inoue H. Gastrointest Endosc. 2016 Apr;83(4):827-8. doi: 10.1016/j.gie.2015.10.005. Epub 2015 Oct 22. No abstract available. PMID: 26472494

A prospective analysis of GERD after POEM on anterior myotomy. Shiwaku H, Inoue H, Sasaki T, Yamashita K, Ohmiya T, Takeno S, Nimura S, Yamashita Y. Surg Endosc. 2016 Jun;30(6):2496-504. doi: 10.1007/s00464-015-4507-0. Epub 2015 Sep 28. PMID: 26416381 Free PMC Article

Long-term prognostic impact of circulating tumour cells in gastric cancer patients.
Hiroaki Ito, Jun Sato, Yukio Tsujino, Noriko Yamaguchi, Satoshi Kimura, Keigo Gohda, Katsuhiro Murakami, Manabu Onimaru, Tohru Ohmori, Fumihiro Ishikawa, and Haruhiro Inoue.
World Journal of Gastroenterology. 2016;22(46):10232-10241.

Change of number and size of circulating tumor cells with high telomerase activity during treatment of patients with gastric cancer.
Hiroaki Ito, Noriko Yamaguchi, Manabu Onimaru, Satoshi Kimura, Tohru Ohmori, Fumihiro Ishikawa, Jun Sato, Shun Ito and Haruhiro Inoue.
Oncology Letters. Oncology Letters. 2016;12: 4720-4726.

2016 総説
【特集】がん医療の新たな展開 - 循環がん細胞研究の最近の知見と将来展望.
伊藤 寛晃.
BIO INDUSTRY 33(5): 38-42, 2016 (シーエムシー出版, 東京, ISSN: 0910-6545).

2016 症例報告
虫垂出血の1例.
保母 貴宏, 面高 俊祐, 小城原 傑, 道端 浩三郎, 磯崎 正典, 佃 玄紀, 松尾 海, 有馬 秀英, 浦上 尚之, 横山 登, 松川 正明, 井上 晴洋.
Progress of Digestive Endoscopy. Vol. 87 (2015) No. 1 p. 172-173 (published online 01 Jan 2016).

右側結腸捻転の1例.
磯崎 正典, 横山 登, 面高 俊祐, 小城原 傑, 道端 浩三郎, 佃 玄紀, 松尾 海, 保母 貴宏, 有馬 秀英, 浦上 尚之, 松川 正明, 井上 晴洋.
Progress of Digestive Endoscopy. Vol. 87 (2015) No. 1 p. 174-175 (published online 01 Jan 2016).

2015 原著論文
Per-Oral Endoscopic Myotomy: A series of 500 patients.
Haruhiro Inoue, Hiroki Sato, Haruo Ikeda, Manabu Onimaru, Chiaki Sato, Hitomi Minami, Hiroshi Yokomichi, Yasutoshi Kobayashi, Kevin L. Grimes, and Shin-ei Kudo.
J Am Coll Surg 2015; 222: 256-64.

Single-incision cholecystectomy in a patient with situs inversus totalis presenting with cholelithiasis: A case report. Deguchi Y, Mitamura K, Omotaka S, Eguchi J, Sakuma D, Sato M, Nomura N, Ito T, Grimes KL, Inoue H. Asian J Endosc Surg. 2015 Aug;8(3):347-9. doi: 10.1111/ases.12180. PMID: 26303735

Double-scope per oral endoscopic myotomy (POEM): a prospective randomized controlled trial. Grimes KL, Inoue H, Onimaru M, Ikeda H, Tansawet A, Bechara R, Tanaka S. Surg Endosc. 2016 Apr;30(4):1344-51. doi: 10.1007/s00464-015-4396-2. Epub 2015 Jul 15. PMID: 26173548

Peroral endoscopic myotomy (POEM) vs laparoscopic Heller myotomy (LHM) for the treatment of Type III achalasia in 75 patients: a multicenter comparative study. Kumbhari V, Tieu AH, Onimaru M, El Zein MH, Teitelbaum EN, Ujiki MB, Gitelis ME, Modayil RJ, Hungness ES, Stavropoulos SN, Shiwaku H, Kunda R, Chiu P, Saxena P, Messallam AA, Inoue H, Khashab MA. Endosc Int Open. 2015 Jun;3(3):E195-201. doi: 10.1055/s-0034-1391668. Epub 2015 Apr 13. PMID: 26171430 Free PMC Article

Endoscopic features of early-stage signet-ring-cell carcinoma of the stomach. Phalanusitthepha C, Grimes KL, Ikeda H, Sato H, Sato C, Hokierti C, Inoue H. World J Gastrointest Endosc. 2015 Jun 25;7(7):741-6. doi: 10.4253/wjge.v7.i7.741. PMID: 26140102 Free PMC Article

In vivo histopathological assessment of the muscularis propria in achalasia by using endocytoscopy (with video). Sato H, Inoue H, Ikeda H, Sato C, Santi EG, Phalanusitthepha C, Aoyagi Y, Kudo SE. Endosc Int Open. 2014 Sep;2(3):E178-82. doi: 10.1055/s-0034-1377319. Epub 2014 Jul 10. PMID: 26134965 Free PMC Article

Endoscopic Ex Vivo Evaluation of Bile Concentrations by Narrow Band Imaging: A Pilot Study. Maselli R, Inoue H, Ikeda H, Onimaru M, Yoshida A, Santi EG, Sato H, Eleftheriadis N, Kudo SE. Gastroenterol Res Pract. 2015;2015:367848. doi: 10.1155/2015/367848. Epub 2015 May 13. PMID: 26074954 Free PMC Article

Endocytoscopic microvasculature evaluation is a reliable new diagnostic method for colorectal lesions (with video). Kudo SE, Misawa M, Wada Y, Nakamura H, Kataoka S, Maeda Y, Toyoshima N, Hayashi S, Kutsukawa M, Oikawa H, Mori Y, Ogata N, Kudo T, Hisayuki T, Hayashi T, Wakamura K, Miyachi H, Ishida F, Inoue H. Gastrointest Endosc. 2015 Nov;82(5):912-23. doi: 10.1016/j.gie.2015.04.039. Epub 2015 Jun 9. PMID: 26071058

Peroral endoscopic myotomy: an evolving treatment for achalasia. Bechara R, Ikeda H, Inoue H. Nat Rev Gastroenterol Hepatol. 2015 Jul;12(7):410-26. doi: 10.1038/nrgastro.2015.87. Epub 2015 Jun 2. Review. Erratum in: Nat Rev Gastroenterol Hepatol. 2015 Jul;12(7):i. PMID: 26035678

Silver Nanoscale Hexagonal Column Chips for Detecting Cell-free DNA and Circulating Nucleosomes in Cancer Patients. Ito H, Hasegawa K, Hasegawa Y, Nishimaki T, Hosomichi K, Kimura S, Ohba M, Yao H, Onimaru M, Inoue I, Inoue H. Sci Rep. 2015 May 21;5:10455. doi: 10.1038/srep10455. PMID: 25994878 Free PMC Article

Recent advancement of therapeutic endoscopy in the esophageal benign diseases. Bechara R, Inoue H. World J Gastrointest Endosc. 2015 May 16;7(5):481-95. doi: 10.4253/wjge.v7.i5.481. Review. PMID: 25992187 Free PMC Article

Nutcracker and jackhammer esophagus treatment: a three-case survey, including two novel cases of eosinophilic infiltration into the muscularis propria. Sato H, Takeuchi M, Takahashi K, Sato Y, Hashimoto S, Mizuno K, Suzuki K, Kobayashi M, Honma T, Inoue H, Terai S. Endoscopy. 2015 Sep;47(9):855-7. doi: 10.1055/s-0034-1391985. Epub 2015 May 11. PMID: 25961439

In vivo gastric mucosal histopathology using endocytoscopy. Sato H, Inoue H, Ikeda H, Sato C, Phlanusittepha C, Hayee B, Santi EG, Kobayashi Y, Kudo SE. World J Gastroenterol. 2015 Apr 28;21(16):5002-8. doi: 10.3748/wjg.v21.i16.5002. PMID: 25945015 Free PMC Article

Gastroenterological surgery: esophagus. Kitagawa Y, Idani H, Inoue H, Udagawa H, Uyama I, Osugi H, Katada N, Takeuchi H, Akutsu Y, Asami S, Ishikawa K, Okamura A, Ono T, Kato F, Kawabata T, Suda K, Takesue T, Tanaka T, Tsutsui M, Hosoda K, Matsuda S, Matsuda T, Mani M, Miyazaki T. Asian J Endosc Surg. 2015 May;8(2):114-24. doi: 10.1111/ases.12185. No abstract available. PMID: 25913582

Mucostomy closure using the endoloop/clips technique in a purse-string manner after an unsuccessful closure during peroral endoscopic myotomy. Shiwaku H, Inoue H, Yamashita Y. Dig Endosc. 2015 Jul;27(5):630-1. doi: 10.1111/den.12480. Epub 2015 Jun 9. No abstract available. PMID: 25912050

The American Society for Gastrointestinal Endoscopy PIVI (Preservation and Incorporation of Valuable Endoscopic Innovations) on peroral endoscopic myotomy. American Society for Gastrointestinal Endoscopy PIVI Committee, Chandrasekhara V, Desilets D, Falk GW, Inoue H, Romanelli JR, Savides TJ, Stavropoulos SN, Swanstrom LL. Gastrointest Endosc. 2015 May;81(5):1087-100.e1. doi: 10.1016/j.gie.2014.12.007. Epub 2015 Mar 19. No abstract available. PMID: 25799295

Diagnostic performance of endocytoscopy for evaluating the invasion depth of different morphological types of colorectal tumors. Kudo T, Kudo SE, Wakamura K, Mori Y, Misawa M, Hayashi T, Kutsukawa M, Ichimasa K, Miyachi H, Ishida F, Inoue H. Dig Endosc. 2015 Nov;27(7):754-61. doi: 10.1111/den.12469. Epub 2015 Apr 16. PMID: 25777505

Endocytoscopic narrow-band imaging efficiency for evaluation of inflammatory activity in ulcerative colitis. Maeda Y, Ohtsuka K, Kudo SE, Wakamura K, Mori Y, Ogata N, Wada Y, Misawa M, Yamauchi A, Hayashi S, Kudo T, Hayashi T, Miyachi H, Yamamura F, Ishida F, Inoue H, Hamatani S. World J Gastroenterol. 2015 Feb 21;21(7):2108-15. doi: 10.3748/wjg.v21.i7.2108. PMID: 25717245 Free PMC Article

Greater curvature myotomy is a safe and effective modified technique in per-oral endoscopic myotomy (with videos). Onimaru M, Inoue H, Ikeda H, Sato C, Sato H, Phalanusitthepha C, Santi EG, Grimes KL, Ito H, Kudo SE. Gastrointest Endosc. 2015;81(6):1370-7. doi: 10.1016/j.gie.2014.11.014. Epub 2015 Feb 14. PMID: 25686872

New endoscopic indicator of esophageal achalasia: "pinstripe pattern". Minami H, Isomoto H, Miuma S, Kobayashi Y, Yamaguchi N, Urabe S, Matsushima K, Akazawa Y, Ohnita K, Takeshima F, Inoue H, Nakao K. PLoS One. 2015 Feb 9;10(2):e0101833. doi: 10.1371/journal.pone.0101833. eCollection 2015. PMID: 25664812 Free PMC Article

International multicenter experience with peroral endoscopic myotomy for the treatment of spastic esophageal disorders refractory to medical therapy (with video). Khashab MA, Messallam AA, Onimaru M, Teitelbaum EN, Ujiki MB, Gitelis ME, Modayil RJ, Hungness ES, Stavropoulos SN, El Zein MH, Shiwaku H, Kunda R, Repici A, Minami H, Chiu PW, Ponsky J, Kumbhari V, Saxena P, Maydeo AP, Inoue H. Gastrointest Endosc. 2015 May;81(5):1170-7. doi: 10.1016/j.gie.2014.10.011. Epub 2015 Jan 26. PMID: 25634487

Magnification endoscopy in esophageal squamous cell carcinoma: a review of the intrapapillary capillary loop classification. Inoue H, Kaga M, Ikeda H, Sato C, Sato H, Minami H, Santi EG, Hayee B, Eleftheriadis N. Ann Gastroenterol. 2015 Jan-Mar;28(1):41-48. Review. PMID: 25608626 Free PMC Article

Salvage peroral endoscopic myotomy for esophageal diverticulum. Sato H, Sato Y, Takeuchi M, Takahashi K, Takeda SR, Inoue H, Kobayashi M. Endoscopy. 2015;47 Suppl 1 UCTN:E14-5. doi: 10.1055/s-0034-1390735. Epub 2015 Jan 20. No abstract available. PMID: 25603506

Utility of intrapapillary capillary loops seen on magnifying narrow-band imaging in estimating invasive depth of esophageal squamous cell carcinoma. Sato H, Inoue H, Ikeda H, Sato C, Onimaru M, Hayee B, Phlanusi C, Santi EG, Kobayashi Y, Kudo SE. Endoscopy. 2015 Feb;47(2):122-8. doi: 10.1055/s-0034-1390858. Epub 2015 Jan 15. PMID: 25590187

Clinical application of endoscopic ultrasonography for esophageal achalasia. Minami H, Inoue H, Isomoto H, Urabe S, Nakao K. Dig Endosc. 2015 Apr;27 Suppl 1:11-6. doi: 10.1111/den.12432. Review. PMID: 25573637

Efficacy of peroral endoscopic myotomy (POEM) in the treatment of achalasia: a systematic review and meta-analysis. Talukdar R, Inoue H, Nageshwar Reddy D. Surg Endosc. 2015 Nov;29(11):3030-46. doi: 10.1007/s00464-014-4040-6. Epub 2014 Dec 25. Review. PMID: 25539695

Polyps in Lynch syndrome. Differences in quality of colonoscopy between Western and Eastern endoscopists. Eleftheriadis N, Inoue H, Ikeda H, Onimaru M, Maselli R, Kudo SE. Endoscopy. 2015 Jan;47(1):89. doi: 10.1055/s-0034-1378101. Epub 2014 Dec 22. No abstract available. PMID: 25532115

Prevalence of serrated polyposis syndrome and its association with synchronous advanced adenoma and lifestyle. Toyoshima N, Sakamoto T, Makazu M, Nakajima T, Matsuda T, Kushima R, Shimoda T, Fujii T, Inoue H, Kudo SE, Saito Y. Mol Clin Oncol. 2015 Jan;3(1):69-72. Epub 2014 Sep 22. PMID: 25469272 Free PMC Article

In vivo histopathology using endocytoscopy for non-neoplastic changes in the gastric mucosa: a prospective pilot study (with video). Sato H, Inoue H, Hayee B, Ikeda H, Sato C, Phalanusitthepha C, Santi EG, Kobayashi Y, Kudo SE. Gastrointest Endosc. 2015 Apr;81(4):875-81. doi: 10.1016/j.gie.2014.08.019. Epub 2014 Oct 13. PMID: 25442082

Novel computer-aided diagnostic system for colorectal lesions by using endocytoscopy (with videos). Mori Y, Kudo SE, Wakamura K, Misawa M, Ogawa Y, Kutsukawa M, Kudo T, Hayashi T, Miyachi H, Ishida F, Inoue H. Gastrointest Endosc. 2015 Mar;81(3):621-9. doi: 10.1016/j.gie.2014.09.008. Epub 2014 Oct 29. PMID: 25440671 Free Article

Greater curvature myotomy is a safe and effective modified technique in per-oral endoscopic myotomy.
Manabu Onimaru, Haruhiro Inoue, Haruo Ikeda, Chiaki Sato, Hiroki Sato, Chainarong Phalanusitthepha, Esperanza Grace Santi, Kevin L. Grimes, Hiroaki Ito, and Shin-ei Kudo.
Gastrointest Endosc. 2015 Jun;81(6):1370-7. doi: 10.1016/j.gie.2014.11.014 (published online: 14 Feb 2015).

Silver Nanoscale Hexagonal Column Chips for Detecting Cell-free DNA and Circulating Nucleosomes in Cancer Patients.
Hiroaki Ito, Katsuyuki Hasegawa, Yuuki Hasegawa, Tadashi Nishimaki, Kazuyoshi Hosomichi, Satoshi Kimura, Motoi Ohba, Hiroshi Yao, Manabu Onimaru, Ituro Inoue, and Haruhiro Inoue.
Nature Publishing Group, Scientific Reports. 5:10455. doi: 10.1038/srep10455 (published online: 21 May 2015).

Novel methodology for the detection of circulating tumor cells in gastric cancer and cell-free nucleic acids in gastrointestinal malignancies.
Hiroaki Ito, Katsuyuki Hasegawa, Yuuki Hasegawa, Satoshi Kimura, Manabu Onimaru, Noriko Yamaguchi, Haruo Ikeda, Mitsuo Saito, and Haruhiro Inoue.
Science Letters Journal. 2015;4:179.

Change of number and size of circulating tumor cells with high telomerase activity during treatment of patients with gastric cancer.
Hiroaki Ito, Noriko Yamaguchi, Manabu Onimaru, Satoshi Kimura, Tohru Ohmori, Fumihiro Ishikawa, Jun Sato, Shun Ito and Haruhiro Inoue.
Oncology Letters, 2015;12:4720-4726.

2015 総説
Peroral endoscopic myotomy: an evolving treatment for achalasia.
Robert Bechara, Haruo Ikeda, and Haruhiro Inoue.
Nature Reviews Gastroenterology & Hepatology (2015), doi:10.1038/nrgastro.2015.87 (published online 02 June 2015).

特集2. がん診断法の最先端、3. 消化器癌の新たな診断技術開発の試み
伊藤 寛晃, 井上 晴洋.
PET journal (29): 37-39, 2015(先端医療技術研究所, 東京, ISSN: 2186-022X).

2014 原著論文
Submucosal Endoscopy from ESD to POEM and Beyond.
Haruhiro Inoue, Esperanza Grace Santi, Manabu Onimaru, and Shin-ei Kudo.
Gastrointestinal Endoscopy Clinics. 2014;24(2):24, 257–264.

Anti-reflux mucosectomy for gastroesophageal reflux disease in the absence of hiatus hernia: a pilot study.
Haruhiro Inoue, Hiroaki Ito, Haruo Ikeda, Chiaki Sato, Hiroki Sato, Chainarong Phalanusitthepha, Bu’Hussain Hayee, Nikolas Eleftheriadis, and Shin-ei Kudo.
Annals of Gastroenterology. 2014;27(4):1-6.

Peroral endoscopic myotomy for esophageal achalasia. Phalanusitthepha C, Inoue H, Ikeda H, Sato H, Sato C, Hokierti C. Ann Transl Med. 2014 Mar;2(3):31. doi: 10.3978/j.issn.2305-5839.2014.02.04. Review. PMID: 25333007 Free PMC Article

Anti-reflux mucosectomy for gastroesophageal reflux disease in the absence of hiatus hernia: a pilot study. Inoue H, Ito H, Ikeda H, Sato C, Sato H, Phalanusitthepha C, Hayee B, Eleftheriadis N, Kudo SE. Ann Gastroenterol. 2014;27(4):346-351. PMID: 25330784 Free PMC Article

Per-oral endoscopic myotomy: emerging indications and evolving techniques. Minami H, Inoue H, Haji A, Isomoto H, Urabe S, Hashiguchi K, Matsushima K, Akazawa Y, Yamaguchi N, Ohnita K, Takeshima F, Nakao K. Dig Endosc. 2015 Jan;27(2):175-81. doi: 10.1111/den.12328. Epub 2014 Aug 28. Review. PMID: 25040806

Improved optical identification of laterally spreading type "0-IIb" gastric lesion with narrow band imaging magnification endoscopy. Eleftheriadis N, Inoue H, Ikeda H, Maselli R, Onimaru M, Yoshida A, Ito H, Hamatani S, Kudo SE. Ann Gastroenterol. 2014;27(3):267-269. PMID: 24975679 Free PMC Article

Per-oral endoscopic myotomy white paper summary. NOSCAR POEM White Paper Committee, Stavropoulos SN, Desilets DJ, Fuchs KH, Gostout CJ, Haber G, Inoue H, Kochman ML, Modayil R, Savides T, Scott DJ, Swanstrom LL, Vassiliou MC. Gastrointest Endosc. 2014 Jul;80(1):1-15. doi: 10.1016/j.gie.2014.04.014. Review. No abstract available. PMID: 24950639

Per-oral endoscopic myotomy white paper summary. Stavropoulos SN, Desilets DJ, Fuchs KH, Gostout CJ, Haber G, Inoue H, Kochman ML, Modayil R, Savides T, Scott DJ, Swanstrom LL, Vassiliou MC. Surg Endosc. 2014 Jul;28(7):2005-19. doi: 10.1007/s00464-014-3630-7. Epub 2014 Jun 17. No abstract available. PMID: 24935204

Prognostic impact of the number of viable circulating cells with high telomerase activity in gastric cancer patients: a prospective study. Ito H, Inoue H, Kimura S, Ohmori T, Ishikawa F, Gohda K, Sato J. Int J Oncol. 2014 Jul;45(1):227-34. doi: 10.3892/ijo.2014.2409. Epub 2014 Apr 29. PMID: 24788213

Submucosal endoscopy: from ESD to POEM and beyond. Inoue H, Santi EG, Onimaru M, Kudo SE. Gastrointest Endosc Clin N Am. 2014 Apr;24(2):257-64. doi: 10.1016/j.giec.2013.12.003. Review. PMID: 24679236

Background coloration of squamous epithelium in esophago-pharyngeal squamous cell carcinoma: what causes the color change? Minami H, Isomoto H, Nakayama T, Hayashi T, Yamaguchi N, Matsushima K, Akazawa Y, Ohnita K, Takeshima F, Inoue H, Nakao K. PLoS One. 2014 Jan 28;9(1):e85553. doi: 10.1371/journal.pone.0085553. eCollection 2014. PMID: 24489662 Free PMC Article
Evaluation of the safety and efficacy of esophagojejunostomy after totally laparoscopic total gastrectomy using a trans-orally inserted anvil: a single-center comparative study. Ito H, Inoue H, Odaka N, Satodate H, Onimaru M, Ikeda H, Takayanagi D, Nakahara K, Kudo SE. Surg Endosc. 2014 Jun;28(6):1929-35. doi: 10.1007/s00464-014-3417-x. Epub 2014 Feb 1. PMID: 24488351

Acetic acid spray enhances accuracy of narrow-band imaging magnifying endoscopy for endoscopic tissue characterization of early gastric cancer. Eleftheriadis N, Inoue H, Ikeda H, Onimaru M, Yoshida A, Maselli R, Santi G, Kudo SE. Gastrointest Endosc. 2014 May;79(5):712. doi: 10.1016/j.gie.2013.11.033. Epub 2014 Jan 17. No abstract available. PMID: 24444671

Peroral endoscopic myotomy as a platform for the treatment of spastic esophageal disorders refractory to medical therapy (with video). Khashab MA, Saxena P, Kumbhari V, Nandwani M, Roland BC, Stein E, Clarke JO, Stavropoulos S, Inoue H, Pasricha PJ. Gastrointest Endosc. 2014 Jan;79(1):136-9. doi: 10.1016/j.gie.2013.08.021. No abstract available. PMID: 24342590

Jet injection of dyed saline facilitates efficient peroral endoscopic myotomy. Khashab MA, Messallam AA, Saxena P, Kumbhari V, Ricourt E, Aguila G, Roland BC, Stein E, Nandwani M, Inoue H, Clarke JO. Endoscopy. 2014 Apr;46(4):298-301. doi: 10.1055/s-0033-1359024. Epub 2013 Dec 11. PMID: 24338241

Elective use of an uncuffed small-bore cricothyrotomy tube with balloon occlusion of the subglottic airway. Suzuki T, Ikeda H, Iwamoto T, Sano H, Hashimoto M, Oe K, Inoue H, Serada K. Can J Anaesth. 2014 Jan;61(1):39-45. doi: 10.1007/s12630-013-0057-x. Epub 2013 Oct 25. PMID: 24158854

Efficiency of endocytoscopy in differentiating types of serrated polyps. Kutsukawa M, Kudo SE, Ikehara N, Ogawa Y, Wakamura K, Mori Y, Ichimasa K, Misawa M, Kudo T, Wada Y, Hayashi T, Miyachi H, Inoue H, Hamatani S. Gastrointest Endosc. 2014 Apr;79(4):648-56. doi: 10.1016/j.gie.2013.08.029. Epub 2013 Oct 8. PMID: 24119508

Use of surface-enhanced Raman scattering for detection of cancer-related serum-constituents in gastrointestinal cancer patients. Ito H, Inoue H, Hasegawa K, Hasegawa Y, Shimizu T, Kimura S, Onimaru M, Ikeda H, Kudo SE. Nanomedicine. 2014 Apr;10(3):599-608. doi: 10.1016/j.nano.2013.09.006. Epub 2013 Oct 5. PMID: 24103303

Double staining with crystal violet and methylene blue is appropriate for colonic endocytoscopy: an in vivo prospective pilot study. Ichimasa K, Kudo SE, Mori Y, Wakamura K, Ikehara N, Kutsukawa M, Takeda K, Misawa M, Kudo T, Miyachi H, Yamamura F, Ohkoshi S, Hamatani S, Inoue H. Dig Endosc. 2014 May;26(3):403-8. doi: 10.1111/den.12164. Epub 2013 Sep 10. PMID: 24016362 Free PMC Article

Endocytoscopy can provide additional diagnostic ability to magnifying chromoendoscopy for colorectal neoplasms. Kudo SE, Mori Y, Wakamura K, Ikehara N, Ichimasa K, Wada Y, Kutsukawa M, Misawa M, Kudo T, Hayashi T, Miyachi H, Inoue H, Hamatani S. J Gastroenterol Hepatol. 2014 Jan;29(1):83-90. doi: 10.1111/jgh.12374. PMID: 23980563

Use of surface-enhanced Raman scattering for detection of cancer-related serum-constituents in gastrointestinal cancer patients.
Hiroaki Ito, Haruhiro Inoue, Katsuyuki Hasegawa, Yuuki Hasegawa, Takehiko Shimizu, Satoshi Kimura, Manabu Onimaru, Haruo Ikeda, and Shin-ei Kudo.
Nanomedicine: Nanotechnology, Biology and Medicine. 2014;10(3):599-608.

Evaluation of the safety and efficacy of esophagojejunostomy after totally laparoscopic total gastrectomy using a trans-orally inserted anvil: a single-center comparative study.
Hiroaki Ito, Haruhiro Inoue, Noriko Odaka, Hitoshi Satodate, Manabu Onimaru, Haruo Ikeda, Daisuke Takayanagi, Kenta Nakahara, and Shin-ei Kudo.
Surgical Endoscopy. 2014;28(6):1929-1935.

Prognostic impact of the number of viable circulating cells with high telomerase activity in gastric cancer patients: A prospective study.
Hiroaki Ito, Haruhiro Inoue, Satoshi Kimura, Tohru Ohmori, Fumihiro Ishikawa, Keigo Gohda, and Jun Sato.
Internatonal Journal of Oncology. 2014;45:227-234.

Improved optical identification of laterally spreading type “0-IIb” gastric lesion with narrow band imaging magnifi cation endoscopy.
Nikolas Eleftheriadis, Haruhiro Inoue, Haruo Ikeda, Roberta Maselli, Manabu Onimaru, Akira Yoshida, Hiroaki Ito, Shigeharu Hamatani, and Shin-ei Kudo.
Annals of Gastroenterology. 2014;27(3):1-3.

2014 総説
循環腫瘍細胞(CTC)検査 –測定意義と今後の課題-
伊藤 寛晃.
Medical Technology 42(1): 88-91, 2014 (医歯薬出版株式会社, 東京, ISSN: 0389-1887).

2014 症例報告
Silodosin により重篤な薬物性肝障害を惹起した 1 例.
野村 憲弘, 伊藤 敬義, 金田 祥明, 司馬 信一, 保母 貴宏, 林 隆広, 佐藤 雅, 佐久間 大, 江口 潤一, 三田村圭太郎, 出口 義雄, 松川 正明, 斎藤 光次, 井上 晴洋.
肝臓. 2014;55(11):670-676.


研究

 大学機関である当センターは、厚生労働科学研究、科学研究費助成事業(科研費)等の支援を得て、がん診療の最先端技術を開発しています。非常に有望ないくつかの技術をご紹介いたします。
 これらの研究は、いまだ臨床研究の段階であり、お問い合わせをいただきましても対応できない場合がございます。ご理解のほど、宜しくお願い申し上げます。

臨床データ・余剰生体検体活用のお願い

1)超拡大内視鏡による生体内細胞観察(井上 晴洋池田 晴夫 / 厚生労働科学研究)
 消化器がんの確定診断は、通常、内視鏡などで組織を採取し (生検)、病理診断で行いますが、抗凝固療法や抗血小板療法を受けておられる方が増えており、安全に生検を行えない場合もあります。超拡大内視鏡による生体内細胞観察は、検査中に細胞や血管構造の質的診断を行うことが可能であり、生検を行わずに済む可能性があります。
Inoue H, Sasajima K, Kaga M, et al. Endoscopic in vivo evaluation of tissue atypia in the esophagus using a newly designed integrated endocytoscope: a pilot trial. Endoscopy.2006;38:891-895

2)循環がん細胞解析による早期がん診断と新規治療開発(伊藤 寛晃井上 晴洋 / 科研費)
CTCs_Manipulation_01

 がんは周囲に広がる(浸潤)とともに、血液にのってはなれた臓器に転移(血行性転移)することが特徴です。わたしたちは、血液中の循環がん細胞(CTCs)個数が胃がんの予後と相関することを示しました。CTCsを検出することで、がんの早期診断や再発の診断、追加治療の必要性などを判断できる可能性があります。
 CTCsの検出には、通常、抗体などで標識する必要があります。しかし、がんの浸潤・転移メカニズムを解明するためには、なるべく体内の状態のままのCTCs(無標識循環がん細胞、Non-label CTCs)を解析することが重要です。わたしたちは、Non-label CTCsの検出・採取精度を高める研究を行っています。non-label CTCsの特徴を丹念に調べることで、がんの血行性転移に関与する因子を特定し、転移を予防する分子標的治療薬など、新規治療法の開発を目指しています。

Ito H, Inoue H, Sando N, et al. Prognostic impact of detecting viable circulating tumour cells in gastric cancer patients using a telomerase-specific viral agent: a prospective study. BMC Cancer. 2012;12:346
Ito H, Inoue H, Kimura S, et al. Prognostic impact of the number of viable circulating cells with high telomerase activity in gastric cancer patients: A prospective study. Internatonal Journal of Oncology. 2014;45:227-234
Hiroaki Ito, Jun Sato, Yukio Tsujino, et al. Long-term prognostic impact of circulating tumour cells in gastric cancer patients. World Journal of Gastroenterology. 2016;22(46):10232-10241
Hiroaki Ito, Noriko Yamaguchi, Manabu Onimaru, et al. Change of number and size of circulating tumor cells with high telomerase activity during treatment of patients with gastric cancer. Oncology Letters. Oncology Letters. 2016;12: 4720-4726
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