清水 克悦

教員情報

name

SHIMIZU Katsuyoshi

身分

准教授

資格

日本脳神経外科認定医 / 日本脳卒中学会専門医 / 日本神経内視鏡学会技術認定医

専門分野

脳神経外科 / 顔面けいれん、三叉神経痛 / 良性腫瘍(髄膜腫、聴神経腫瘍、下垂体腺腫ほか) / 頭蓋底腫瘍 / 脳血管障害 / 虚血耐性

学位

博士(医学) アデノシンの虚血時脳保護効果についての研究

e-mail

非公開

主な所属

医学部脳神経外科学

最終学歴

慶應義塾大学医学部

担当科目

脳神経外科学

研究内容

虚血耐性の基礎研究 mitochondrial ATP sensitive potassium channel

所属学会

日本脳神経外科学会
日本脳神経外科コングレス
日本脳卒中学会
日本神経内視鏡学会

受賞、表彰

著作、論文

1. Shimizu, K., Ogino, M., Yamaguchi, N., Mitani, S., Saito, R., Kawase, T., and Toya, S.: Propentofylline (HWA285) inhibits the release of dopamine during transient ischemia and modulates its metabolism in rat striatum. Neurosci Lett. 158: 9-12, 1993

2. Shimizu, K. The neuroprotective effects of adenosine against ischemic insult in rat striatum - A study using in vivo microdialysis - . The Keio Journal of Medicine 72: 353-364, 1995

3. 古旗茂、清水克悦、高宮至昭 意欲障害,知的機能障害のみならず,情緒障害にもプロペントフィリンが著効を示した脳梗塞後遺症患者の1症例
老化と疾患 vol.8 (No. 9), 60-62, 1995

4. Shimizu, K., Yamada, F., Fukuda, S., and Toya, S. Spontaneous disappearance of a cerebral arteriovenous malformation. - Case report - . Neurol Med Chir 36: 26-30, 1996

5. 古旗茂、清水克悦、高宮至昭 クモ膜下出血で発症したAVM症例の検討 東京都医師会雑誌 48: 1499-1500, 1996

6. 古旗茂、清水克悦、高宮至昭 脳幹梗塞による手掌口症候群の一例
東京都医師会雑誌 49: 1190-1191, 1996

7. 古旗茂、成高平治、高宮至昭、清水克悦、亀谷徹 プロラクチン産生腺腫と成長ホルモン産生腺腫の分類検討および、後者と糖蛋白ホルモンαサブユニットの意義 ホルモンと臨床(増)44: 106-110, 1996

8. Ishikawa, M., Sekizuka, E., Shimizu, K., Yamaguchi, N., and Kawase, T. Measurement of RBC velocities in the rat pial arteries with an image-intensified high-speed video camera system. Microvascular Research 56: 166-172. 1998

9. Ishikawa, M., Sekizuka, E., Sato, S., Shimizu, K., Yamaguchi, N., and Kawase, T. In vivo rat closed spinal window for spinal microcirculation: observation of pial vessels, leukocyte adhesion, and red blood cell velocity. Neurosurgery 44: 156-161, 1999

10. Shimizu, K., Furuhata, S., Sasai, S., Tominaga, S., and Takamiya, Y. Intracerebral cystic meningioma - case report. Neurol Med Chir 39: 530-533, 1999

11. Shimizu, K., Takamiya, Y., Furuhata, S., Naritaka, H., and Kameya, T. Cystic lesion at the foramen magnum disseminated from a pituitary adenoma - case report. Neurol Med Chir 39: 606-611, 1999

12. Shimizu, K., Veltkamp, R., and Busija, D.W. Characteristics of induced spreading depression after transient focal ischemia in the rat. Brain Res 861: 316-324, 2000

13. Shimizu, K., Bari, F., and Busija, D.W. Glibenclamide enhances cortical spreading depression-associated hyperemia in the rat. Neuroreport 11: 2103-2106, 2000

14. Rajapakse, N., Shimizu, K., Payne, M. and Busija, D. Isolation and characterization of intact mitochondria from neonatal rat brain. Brain Res Brain Res Protoc, 8:176-83, 2001

15. 留学報告「米国留学を終えて」刀林 78: 7, 2001. 12. 17.

16. Shimizu, K., Miller, AW., Erdo-s, B., Bari, F., Busija, D.W. Role of endothelium in hyperemia during cortical spreading depression (CSD) in the rat. Brain Res 928: 40-49, 2002

17. Domoki F, Perciaccante JV, Shimizu K, Puskar M, Busija DW, Bari F. N-methyl-D-aspartate-induced vasodilation is mediated by endothelium-independent nitric oxide release in piglets. Am J Physiol Heart Circ Physiol 282: H1404-9, 2002

18. Rajapakse N., Shimizu K., Snipes J., Lacza Z., Busija D.W.. Activation of mitochondrial ATP-sensitive potassium channels prevents neuronal cell death after ischemia in neonatal rats. Neurosci Lett 327: 208-212, 2002

19. Horiguchi T, Shima H, Suga S, Ogino M, Shimizu K, Toya S, Nagao M, Kawase
T. Transient forebrain ischemia induces expression of serine/threonine protein phosphatase 1 mRNA in the vulnerable regions of gerbil brain. Neurosci Lett 325:115-8, 2002

20. Shimizu, K., Lacza, Z., Rajapakse, N., Horiguchi, T., Snipes, J., Busija, D.W..
MitoKATP opener, diazoxide, reduces neuronal damage after middle cerebral artery occlusion in the rat. Am J Physiol Heart Circ Physiol 283: H1005-1011, 2002

21. Horiguchi, T., Shimizu, K., Ogino, M., Yamaguchi, N., Suga, S., Inamasu, J., Kawase, T. Neuroprotection role of adenosine under hypothermia in the rat global ischemia involves inhibition of not dopamine release but delayed postischemic hypoperfusion. Brain Res 952: 222-231, 2002

22. Veltkamp R, Rajapakse N, Robins G, Puskar M, Shimizu K, Busija DW. Transient focal ischemia increases endothelial nitric oxide synthase in cerebral blood vessels. Stroke 33: 2704-10, 2002

23. Shimizu, K., Rajapakse, N., Horiguchi, T., Payne, R.M., Busija, D.W. Protective effect of a new nonpeptydil mimetic of SOD, M40401 against focal cerebral ischemia in the rat. Brain Res 963: 8-14, 2003

24. Horiguchi, T., Kis, B., Rajapakse N., Shimizu, K., Busija, D.W. Opening of Mitochondrial ATP-sensitive potassium channels is a trigger of 3-nitropropionic acid-induced tolerance to transient focal cerebral ischemia in rats. Stroke 34: 1015-1020, 2003

25. Shimizu, K., Rajapakse, N., Horiguchi, T., Payne, R.M., Busija, D.W. Neuroprotection against hypoxia-ischemia in neonatal rat by novel superoxide dismutase mimetics. Neurosci Lett 346: 41-44, 2003

26. Horiguchi, T., Shimizu, K., Ogino, M., Suga, S., Inamasu, J., Kawase, T. Postischemic hypothermia inhibits the generation of hydroxyl radical following transient forebrain ischemia in rats. J Neurotrauma 20: 511-520, 2003

27. 私の研究「虚血脳障害のメカニズムの解明」刀林 81: 7, 2003. 5. 9

28. Busija DW, Lacza Z, Rajapakse N, Shimizu K, Kis B, Bari F, Domoki F, Horiguchi T. Targeting mitochondrial ATP-sensitive potassium channels--a novel approach to neuroprotection. Brain Res Rev 46: 282-294, 2004

29. Horiguchi T, Snipes JA, Kis B, Shimizu K, Busija DW. The role of nitric oxide in the development of cortical spreading depression-induced tolerance to transient focal cerebral ischemia in rats. Brain Res 1039: 84-89, 2005

30. 清水克悦 13C-MRSによるサルの脳グルコース代謝 慶應医学 82(2): 75-77, 2005

31. Horiguchi T, Kis B, Rajapakse N, Shimizu K, Busija DW. Cortical spreading depression (CSD)-induced tolerance to transient focal cerebral ischemia in halothane anesthetized rats is affected by anesthetic level but not ATP-sensitive potassium channels. Brain Res. 1062: 127-33, 2005

32. Horiguchi T, Snipes JA, Kis B, Shimizu K, Busija DW. Cyclooxygenase-2 mediates the development of cortical spreading depression-induced tolerance to transient focal cerebral ischemia in rats. Neuroscience 140(2):723-30, 2006

33. Busija DW, Bari F, Domoki F, Horiguchi T, Shimizu K. Mechanisms involved in the cerebrovascular dilator effects of cortical spreading depression. Prog
Neurobiol. 86(4): 417-33, 2008

34. Shimizu K, Ochiai M. Primary diffuse B-cell lymphoma presenting as a subdural tumor associated with calcified chronic subdural hematoma. Case report and review of the literature. Chirurgia 25(1): 77-81, 2012

その他

2010年 FNNスーパーニュース
2011年 TBSテレビ「ひるおび!」  で紹介 片側顔面けいれん

2012年
「たけしの健康エンターテインメント! みんなの家庭の医学」 出演 片側顔面けいれん

清水克悦 准教授.JPG