Yamamoto T, Horii I, Yoshida T
Integrated NMR-based metabonomic investigation of early metabolic effects of
ethylene glycol monomethyl ether (egme) on male reproductive organs in rats
J Toxicol Sci 2007 Dec;32(5):515-28 PubMed
Tsujikawa K, Kuwayama K, Miyaguchi H, Kanamori T, Iwata Y, Inoue H, Yoshida T, Kishi T
Determination of muscimol and ibotenic acid in Amanita mushrooms
by high-performance liquid chromatography and liquid chromatography-tandem mass spectrometry
J Chromatogr B Analyt Technol Biomed Life Sci 2007 Jun 1;852(1-2):430-5 PubMed
Naito S, Furuta S, Yoshida T, Kitada M, Fueki O, Unno T, Ohno Y, Onodera H,
Kawamura N, Kurokawa M, Sagami F, Shinoda K, Nakazawa T, Yamazaki T
Current opinion: safety evaluation of drug metabolites in development of pharmaceuticals
J Toxicol Sci 2007 Oct;32(4):329-41 PubMed
Kim BC, Jeon WK, Hong HY, Jeon KB, Hahn JH, Kim YM, Numazawa S, Yosida T,
Park EH, Lim CJ
The anti-inflammatory activity of Phellinus linteus (Berk. & M.A. Curt.) is mediated through
the PKCdelta/Nrf2/ARE signaling to up-regulation of heme oxygenase-1
J Ethnopharmacol 2007 Sep 5;113(2):240-7 PubMed
Koyama K, Suzuki R, Yoshida T, Kikuno T
Usefulness of serum concentration measurement for acute pentobarbital intoxication in patients
Chudoku Kenkyu 2007 Jan;20(1):45-53 PubMed
Ashino T, Arima Y, Shioda S, Iwakura Y, Numazawa S, Yoshida T
Effect of interleukin-6 neutralization on CYP3A11 and metallothionein-1/2 expressions
in arthritic mouse liver
Eur J Pharmacol 2007 Mar 8;558(1-3):199-207 PubMed
Shindo S, Numazawa S, Yoshida T
A physiological role of AMP-activated protein kinase in phenobarbital-mediated
constitutive androstane receptor activation and CYP2B induction
Biochem J 2007 Feb 1;401(3):735-41 PubMed

2007

Tsujikawa K, Kuwayama K, Miyaguchi H, Kanamori T, Iwata YT, Yoshida T, Inoue H

Development of an on-site screening system for amphetamine-type stimulant tablets with a portable attenuated total reflection Fourier transform infrared spectrometer

Anal Chim Acta 2008 Feb 4;608(1):95-103 PubMed
Yoshida T

Preparedness response to hazard and toxic incidents and food terrorism

Yakugaku Zasshi 2008 Jun;128(6):851-7 PubMed
Ashino T, Yamanaka R, Yamamoto M, Shimokawa H, Sekikawa K, Iwakura Y, Shioda S,
Numazawa S, Yoshida T.
Negative feedback regulation of lipopolysaccharide-induced inducible nitric oxide synthase
gene expression by heme oxygenase-1 induction in macrophages.
Mol Immunol 2008 Apr;45(7):2106-15 PubMed
Kageyama H, Takenoya F, Hori Y, Yoshida T, Shioda S
Morphological interaction between galanin-like peptide- and dopamine-containing neurons
in the rat arcuate nucleus
Regul Pept 2008 Jan 10;145(1-3):165-8 PubMed
Hori Y, Kageyama H, Guan JL, Kohno D, Yada T, Takenoya F, Nonaka N, Kangawa K,
Shioda S, Yoshida T
Synaptic interaction between ghrelin- and ghrelin-containing neurons in the rat hypothalamus
Regul Pept 2008 Jan 10;145(1-3):122-7 PubMed
Numazawa S, Sakaguchi H, Aoki R, Taira T, Yoshida T

Regulation of the susceptibility to oxidative stress by cysteine availability in pancreatic beta-cells.

Am J Physiol Cell Physiol 2008 Aug;295(2):C468-74 PubMed

2008

Tsujikawa K, Kuwayama K, Miyaguchi H, Kanamori T, Iwata YT, Yoshida T, Inoue H

Determination of salvinorin A and salvinorin B in Salvia divinorum-related products circulated in Japan.

Forensic Sci Int 2008 Sep 18;180(2-3):105-9 PubMed
Tanaka S, Yamagishi R, Tsutsui M, Kishida T, Murakami M, Kuroda J, Yoshida T
Tissue- and dose-dependent alteration of stress-inducible proteins
by beta2-adrenoceptor agonist, salbutamol, in rats.
J Toxicol Sci 2005 Dec;30(4):305-14 PubMed

2005

Numazawa S, Shindo S, Maruyama K, Chibana F, Kawahara Y, Ashino T, Tanaka S, Yoshida T
Impaired nuclear translocation of CAR in hepatic preneoplastic lesions: Association
with an attenuated CYP2B induction by phenobarbital
FEBS Lett 2005 Jul 4;579(17):3560-4 PubMed
Ishikawa M, Numazawa S, Yoshida T
Redox regulation of the transcriptional repressor Bach1
Free Radic Biol Med 2005 May 15;38(10):1344-1352 PubMed
Oguro T, Yoshida T
Induction of stress responsive protein, heme oxygenase-1 and metallothionein-I and -II
by oxidative stress
Curr Top Pharmacol 2004 8:265-275
Kaneko S, Manabe A, Numazawa S, Itoh K, Inoue M, Yoshida T, Hisamitsu H, Sasa R
Bisphenol-A contents in materials used in pediatric dentistry
Pediat Dent J 2004 Oct;14:17-21
Tanaka S, Momose Y, Tsutsui M, Kishida T, Kuroda J, Shibata N, Yoshida T, Yamagishi R
Quantitative estimation of myocardial fibrosis based on receptor occupancy
for beta2-adrenergic receptor agonists in rats
J Toxicol Sci 2004 Aug;29(3):179-86 PubMed

2004

Numazawa S, Yoshida T
Nrf2-dependent gene expressions: a molecular toxicological aspect
J Toxicol Sci 2004 May;29(2):81-89 PubMed
Ashino T, Oguro T, Shioda S, Horai R, Asano M, Sekikawa K, Iwakura Y, Numazawa S,
Yoshida T
Involvement of interleukin-6 and tumor necrosis factor alpha in CYP3A11 and 2C29 down-regulation
by Bacillus Calmette-Guerin and lipopolysaccharide in mouse liver
Drug Metab Dispos 2004 Jul;32(7):707-714 PubMed

2003

Tanaka S, Tsuchida A, Kiuchi Y, Oguchi K, Numazawa S, Yoshida T
GABAergic modulation of hippocampal glutamatergic neurons: an in vivo microdialysis study
Eur J Pharmacol 2003 Mar 28;465(1-2):61-7 PubMed
Numazawa S, Ishikawa M, Yoshida A, Tanaka S, Yoshida T
Atypical protein kinase C mediates activation of NF-E2-related factor 2 in response to oxidative stress
Am J Physiol Cell Physiol 2003 Aug;285(2):C334-342 PubMed
Numazawa S, Watabe M, Nishimura S, Kurosawa M, Izuno M, Yoshida T
Regulation of ERK-mediated signal transduction by p38 MAP kinase in human monocytic THP-1 cells
J Biochem (Tokyo) 2003 May;133(5):599-605 PubMed
Ashino T, Ozawa S, Numazawa S, Yoshida T
Tissue-dependent induction of heme oxygenase-1 and metallothionein-1/2 by methyl methanesulfonate
J Toxicol Sci 2003 Aug;28(3):181-189 PubMed
Watabe M, Isogai Y, Numazawa S, Yoshida T
Role of c-Myc in nitric oxide-mediated suppression of cytochrome P450 3A4
Life Sci 2003 Nov 21;74(1):99-108 PubMed

2002

Asano T, Ishihara K, Wakui Y, Yanagisawa T, Kimura M, Kamei H, Yoshida T, Kuroiwa Y,
Fujii Y, Yamashita M, Kuramochi T, Tomisawa H, Tateishi M
Absorption, distribution and excretion of 3H-labeled cephaeline- and emetine-spiked ipecac syrup in rats
Eur J Drug Metab Pharmacokinet 2002 Jan-Mar;27(1):17-27 PubMed
Asano T, Watanabe J, Sadakane C, Ishihara K, Hirakura K, Wakui Y, Yanagisawa T, Kimura M,
Kamei H, Yoshida T, Fujii Y, Yamashita M
Biotransformation of the ipecac alkaloids cephaeline and emetine from ipecac syrup in rats
Eur J Drug Metab Pharmacokinet 2002 Jan-Mar;27(1):29-35 PubMed
Kobayashi Y, Suzuki M, Ohshiro N, Sunagawa T, Sasaki T, Oguro T, Tokuyama S, Yamamoto T,
Yoshida T
Induction and inhibition of cytochrome P450 and drug-metabolizing enzymes by climbazole
Biol Pharm Bull 2002 Jan;25(1):53-57 PubMed
Oguro T, Takahashi Y, Ashino T, Takaki A, Shioda S, Horai R, Asano M, Sekikawa K,
Iwakura Y, Yoshida T
Involvement of tumor necrosis factor alpha, rather than interleukin-1alpha/beta or nitric oxides
in the heme oxygenase-1 gene expression by lipopolysaccharide in the mouse liver
FEBS Lett 2002 Apr 10;516(1-3):63-66 PubMed

2001

Sasaki M, Nakayama M, Numazawa S, Oguro T, Honma S, Iwamura S, Tsukamoto K, Yoshida T
Cytochrome P450 enzymes involved in the metabolic pathway
of the histamine 2 (H2)-receptor antagonist roxatidine acetate by human liver microsomes
Arzneimittelforschung 2001 51(8):651-658 PubMed
Asano T, Kushida H, Sadakane C, Ishihara K, Wakui Y, Yanagisawa T, Kimura M, Kamei H,
Yoshida T
Metabolism of ipecac alkaloids cephaeline and emetine
by human hepatic microsomal cytochrome P450s, and their inhibitory effects on P450 enzyme activities
Biol Pharm Bull 2001 Jun;24(6):678-682 PubMed
Kobayashi K, Kogo M, Tani M, Shimada N, Ishizaki T, Numazawa S, Yoshida T, Yamamoto T,
Kuroiwa Y, Chiba K
Role of CYP2C19 in stereoselective hydroxylation of mephobarbital by human liver microsomes
Drug Metab Dispos 2001 Jan;29(1):36-40 PubMed
Kurosawa M, Tani Y, Nishimura S, Numazawa S, Yoshida T
Distinct PKC isozymes regulate bufalin-induced differentiation and apoptosis in human monocytic cells
Am J Physiol Cell Physiol 2001 Mar;280(3):C459-464 PubMed
Oda M, Kurosawa M, Numazawa S, Tanaka S, Akizawa T, Ito K, Maeda M, Yoshida T
Determination of bufalin-like immunoreactivity in serum of humans and rats
by time-resolved fluoroimmunoassay for using a monoclonal antibody
Life Sci 2001 Jan 26;68(10):1107-1117 PubMed
Oguro T, Yoshida T
Effect of ultraviolet A on ornithine decarboxylase and metallothionein gene expression in mouse skin
Photodermatol Photoimmunol Photomed 2001 Apr;17(2):71-78 PubMed
Kobayashi Y, Ohshiro N, Sasaki T, Tokuyama S, Tobe T, Yoshida T, Yamamoto T
Effect of 4-(4-chlorobenzyl)pyridine on rat hepatic microsomal cytochrome P450
and drug-metabolizing enzymes in vivo and in vitro
Biol Pharm Bull 2001 May;24(5):505-509 PubMed
Tanaka S, Okuno Y, Numazawa S, Yamamoto T, Shioda S, Yoshida T
Brain responses to acute withdrawal in phenobarbital-dependent rats
Eur J Pharmacol 2001 Jun 8;421(2):101-108 PubMed
Kobayashi Y, Suzuki M, Ohshiro N, Sunagawa T, Sasaki T, Tokuyama S, Yamamoto T,
Yoshida T
Climbazole is a new potent inducer of rat hepatic cytochrome P450
J Toxicol Sci 2001 Aug;26(3):141-150 PubMed

(2001~ の研究業績を記してあります。)

2011

Ashino T, Sudhahar V, Urao N, Oshikawa J, Chen GF, Wang H, Huo Y, Finney L, Vogt S, McKinney RD, Maryon EB, Kaplan JH, Ushio-Fukai M, Fukai T

Unexpected role of the copper transporter ATP7A in PDGF-induced vascular smooth muscle cell migration

Circ Res 2010 Sep 17;107(6):787-99 PubMed

Watanabe H, Tohyama M, Kamijima M, Nakajima T, Yoshida T, Hashimoto K, Iijima M

Occupational trichloroethylene hypersensitivity syndrome with human herpesvirus-6 and cytomegalovirus reactivation

Dermatology 2010 Aug;221(1):17-22 PubMed

2010

Tanaka S, Tsutsui M, Kishida T, Souma S, Kuroda J, Yoshida T

Salbutamol inhibits lipopolysaccharide-induced inflammatory responses in rat peritoneal macrophages

J Toxicol Sci 2010 35(3):327-34 PubMed

Kaizaki A, Tanaka S, Tsujikawa K, Numazawa S, Yoshida T

Recreational drugs, 3,4-Methylenedioxymethamphetamine(MDMA), 3,4-methylenedioxyamphetamine (MDA) and diphenylprolinol, inhibit neurite outgrowth in PC12 cells

J Toxicol Sci 2010 35(3):375-81 PubMed

Tanaka S, Kondo H, Kanda K, Ashino T, Nakamachi T, Sekikawa K, Iwakura Y, Shioda S, Numazawa S, Yoshida T

Involvement of interleukin-1 in lipopolysaccaride-induced microglial activation and learning and memory deficits

J Neurosci Res 2011 Apr;89(4):506-14 PubMed

Numazawa S, Sugihara K, Miyake S, Tomiyama H, Hida A, Hatsuno M, Yamamoto M, Yoshida T

Possible involvement of oxidative stress in 5-fluorouracil-mediated myelosuppression in mice

Basic Clin Pharmacol Toxicol 2011 Jan;108(1):40-5 PubMed
Takahashi M, Nagashima M, Suzuki J, Seto T, Yasuda I, Yoshida T

Creation and application of psychoactive designer drugs data library using liquid chromatography with photodiode array spectrophotometry detector and gas chromatography-mass spectrometry

Talanta 2009 Feb 15;77(4):1245-72 PubMed

2009

Kojima M, Ashino T, Yoshida T, Iwakura Y, Sekimoto M, Degawa M

IL-1 regulates the Cyp7a1 gene and serum total cholesterol level at steady state in mice.

Biochem Biophys Res Commun 2009 Feb 6;379(2):239-42 PubMed
教授挨拶
昭和大学ホームページ
Fukano Y, Yoshimura H, Yoshida T
Heme oxygenase-1 gene expression in human alveolar epithelial cells (A549) following exposure
to whole cigarette smoke on a direct in vitro exposure system
Exp Toxicol Pathol 2006 Jul;57(5-6):411-8 PubMed
Kaizaki A, Tanaka S, Ishige K, Numazawa S, Yoshida T
The neuroprotective effect of heme oxygenase (HO) on oxidative stress
in HO-1 siRNA-transfected HT22 cells
Brain Res 2006 Sep 7;1108(1):39-44 PubMed
Fukano Y, Oishi M, Chibana F, Numazawa S, Yoshida T
Analysis of the expression of heme oxygenase-1 gene
in human alveolar epithelial cells exposed to cigarette smoke condensate
J Toxicol Sci 2006 May;31(2):99-109 PubMed
Tanaka S, Ide M, Shibutani T, Ohtaki H, Numazawa S, Shioda S, Yoshida T
Lipopolysaccharide-induced microglial activation induces learning
and memory deficits without neuronal cell death in rats
J Neurosci Res 2006 Mar;83(4):557-66 PubMed
Nishimaki-Mogami T, Kawahara Y, Tamehiro N, Yoshida T, Inoue K, Ohno Y, Nagao T, Une M
5Alpha-bile alcohols function as farnesoid X receptor antagonists
Biochem Biophys Res Commun 2006 Jan 6;339(1):386-91 PubMed

2006