原著論文

分子・遺伝子同定班

Kurosawa T, Yamada A, Suzuki D, Morimura N, Sasagane Y, Itabe H, Kamijo R. Nephronectin expression is up-regulated by BMP-2. Biol. Pharm. Bull., 2016, 39:1211-1215. doi: 10.1248/bpb.b15-00941.

Miyazaki T, Tonami K, Hata S, Aiuchi T, Ohnishi K, Lei X-F, Kim-Kaneyama J, Takeya M, Itabe, H, Sorimachi H, Kurihara H, Miyazaki A.: Disturbance of pre-mRNA splicing by calpain-6 aggravates pinocytotic cholesterol deposition in macrophages. J. Clin. Invest. 2016, 126:3417-3432. doi: 10.1172/JCI85880.

Ishizuka M, Kato R, Moriya Y, Noguchi E, Koide Y, Inoue S, Itabe H, Yamamoto M.: Changes in apolipoprotein B and oxidized low-density lipoprotein levels in gingival crevicular fluids caused by periodontal tissue conditions. J. Periodont. Res. 2017, E-pub. doi: 10.1111/jre.12427

Moriya Y, Obama T, Aiuchi T, Sugiyama T, Endo Y, Koide Y, Noguchi E, Ishizuka M, Inoue M, Itabe H, Yamamoto M.: Quantitative proteomic analysis of gingival crevicular fluids from deciduous and permanent teeth. J. Clin. Periodontol. 2017, E-pub. doi: 10.1111/jcpe.12696.

Yamada S ,Koike T, Nakagawa T, Kuniyoshi N, Ying Y, Itabe H, Yamashita A, Asada Y, Shiomi M.: Morphological features of coronary plaques in WHHLMI rabbits (Oryctolagus cuniculus), an animal model for familial hypercholesterolemia. Experimental Animals, 2016, E-pub. doi: 10.1538/expanim.16-0078

Arai T, Ohno A, Mori K, Kakizawa T, Kuwata H, Ozawa T, Shibanuma M, Hara S, Ishida S, Kurihara M, Miyata N, Nakagawa H, Fukuhara K : Design, synthesis, and evaluation of Trolox-conjugated amyloid-β C-terminal peptides for therapeutic intervention in an in vitro model of Alzheimer's disease. Bioorg Med Chem, 24 : 4138-4143, 2016(査読有)

Arai T, Ohno A, Mori K, Kuwata H, Mizuno M, Imai K, Hara S, Shibanuma M, Kurihara M, Miyata N, Nakagawa H, Fukuhara K : Inhibition of amyloid fibril formation and cytotoxicity by caffeic acid-conjugated amyloid-β C-terminal peptides. Bioorg Med Chem Lett, 26 : 5468-5471, 2016(査読有)

*Mizuho M, Nakanishi I, Matsubayashi S, Imai K, Arai T, Matsumoto K, Fukuhara K : Synthesis and antioxidant activity of a procyanidin B3 analogue. Bioorg. Med. Chem. Lett. 27 : 1041-1044, 2017 (査読有).

Arai T, Ohno A, Mori K, Kuwata H, Mizuno M, Imai K, Hara S, Shibanuma M, Kurihara M, Miyata N, Nakagawa H, Fukuhara K : Inhibition of amyloid fibril formation and cytotoxicity by caffeic acid-conjugated amyloid-ß C-terminal peptides. Bioorg. Med. Chem. Lett. 26 : 5468-5471, 2016 (査読有).

Arai T, Ohno A, Mori K, Kakizawa T, Kuwata H, Ozawa T, Shibanuma M, Hara S, Ishida S, Kurihara M, Miyata N, Nakagawa H, Fukuahra K : Design, synthesis and evaluation of Trolox-conjugated amyloid- ß C-terminal peptides for therapeutic intervention in an in vitro model of Alzheimer’s disease. Bioorg. Med. Chem. 24 : 4138-4143, 2016 (査読有).

Kumamoto H, Fukano M, Nakano T, Iwagami K, Takeyama C, Kohgo S, Imoto S, Amano M, Kuwata-Higashi N, Aoki M, Abe H, Mitsuya H, Fukuhara K, Haraguchi K : Diastereoselective synthesis of 6’’-(Z)- and 6’’-(E)-fluoro analogues of anti-hepatitis B virus agent Entecavir and its evaluation of the activity and toxicity profile of the diastereomers. J. Org. Chem. 81 : 2827-2836, 2016 (査読有).

Tabei Y, Sonoda A, Nakajima Y, Biju V, Makita Y, Yoshida Y, Horie M. Intracellular accumulation of indium ions released from nanoparticles induces oxidative stress, proinflammatory response and DNA damage. J Biochem. 159, 225-237, 2016.

Murotomi K, Arai S, Uchida S, Endo S, Mitsuzumi H, Tabei Y, Yoshida Y, Nakajima Y. Involvement of splenic iron accumulation in the development of nonalcoholic steatohepatitis in Tsumura Suzuki Obese Diabetes mice. Sci Rep. 2, 22476, 2016.

Horie M, Sugino S, Kato H, Tabei Y, Nakamura A, Yoshida Y. Does photocatalytic activity of TiO2 nanoparticles correspond to photo-cytotoxicity? Cellular uptake of TiO2 nanoparticles is important in their photo-cytotoxicity.　 Toxicol Mech Methods. 26, 284-294, 2016.

Otsuki N, Homma T, Fujiwara H, Kaneko K, Hozumi Y, Shichiri M, Takashima M, Ito J, Konno T, Kurahashi T, Yoshida Y, Goto K, Fujii S, Fujii J. Trichloroethylene exposure aggravates behavioral abnormalities in mice that are deficient in superoxide dismutase. Regul Toxicol Pharmacol. 79, 83-90, 2016.

Saito Y, Akazawa-Ogawa Y, Matsumura A, Saigoh K, Itoh S, Sutou K, Kobayashi M, Mita Y, Shichiri M, Hisahara S, Hara Y, Fujimura H, Takamatsu H, Hagihara Y, Yoshida Y, Hamakubo T, Kusunoki S, Shimohama S, Noguchi N. Oxidation and interaction of DJ-1 with 20S proteasome in the erythrocytes of early stage Parkinson's disease patients. Sci Rep. doi: 10.1038/srep30793, 2016.

Homma T, Akihara R, Okano S, Shichiri M, Yoshida Y, Yamada KI, Miyata S, Nakajima O, Fujii J. Heightened aggressive behavior in mice deficient in aldo-keto reductase 1a (Akr1a). Behav Brain Res. 319, 219-224, 2017.

Horie M, Nara K, Sugino S, Umeno A, Yoshida Y. Comparison of antioxidant activities among four kinds of Japanese traditional fermented tea. Food Sci Nutr. 1-7, 2016.

Dong J, Shichiri M, Chung CI, Shibata T, Uchida K, Hagihara Y, Yoshida Y, Ueda H. An open sandwich immunoassay for detection of 13(R,S)-hydroxy-9(E),11(E)-octadecadienoic acid. Analyst, in press, 2017.

細胞機能制御班:

Urano-Morisawa E, Takami M, Suzawa T, Matsumoto A, Osumi N, Baba K, Kamijo R. Induction of osteoblastic differentiation of neural crest-derived stem cells from hair follicles. PLoS One. 2017 Apr 6;12(4):e0174940. doi: 10.1371/journal.pone.0174940. Collection 2017.（査読有）

*Saito A, Yoshimura K, Miyamoto Y, Kaneko K, Chikazu D, Yamamoto M, Kamijo R: Enhanced and suppressed mineralization by acetoacetate and β-hydroxybutyrate in osteoblast cultures. Biochem Biophys Res Commun, 473:537-544, 2016 (査読有)
Kurosawa T, Yamada A, Suzuki D, Morimura N, Sasagane Y, Itabe H, Kamijo R: Nephronectin expression is up-regulated by BMP-2. Biol Pharm Bull, 39:1211-1215, 2016 (査読有)

Konno A, Nishimura A, Nakayama S, Mochizuki A, Yamada A, Kamijo R, Inoue T, Iijima T: Continuous monitoring of caspase-3 activation induced by propofol in developing mouse brain. J Dev Neurosci, 51:42-49, 2016 (査読有)

Hiranuma K, Yamada A, Kurosawa T, Aizawa R, Suzuki D, Saito Y, Nagahama R, Ikehata M, Tsukasaki M, Morimura N, Chikazu D, Maki K, Shirota T, Takami M, Yamamoto M, Iijima T, Kamijo R: Expression of nephronectin is enhanced by 1α,25-dihydroxyvitamin D3. FEBS Open Bio, 6:914-918, 2016 (査読有)

Miyamoto Y, Akaike T, Kawabata S, Akuta T, Taruki C, Yochitake J, Hamada S, Ota F, Igarashi H, Yoshimura K, Kamijo R, Maeda H: Degradation of bradykinin by a metalloendopeptidase from Streptococcus pyogenes. J Oral Biosci, 58:167-172, 2016 (査読有)

Yamaguchi T, Hosomichi K, Yano K, Kim TI, Nakaoka H, Kimura R, Otsuka H, Nonaka N, Haga S, Takahashi M, Shirota T, Kikkawa Y, Yamada A, Kamijo R, Park SB, Nakamura M, Maki K, Inoue I: Comprehensive genetic exploration of selective tooth agenesis of mandibular incisors by exome sequencing. Human Genome Variation, 4:17005. 2017 (査読有)

Ikehata M, Yamada A, Morimura N, Itose M, Suzawa T, Shirota T, Chikazu D, Kamijo R: Wnt/b-catenin signaling activates nephronectin expression in osteoblasts. Biochem Biophys Res Commun, 484:231-234, 2017 (査読有)

*Mori K, Uchida T, Fukumura M, Tamiya S, Higurashi M, Sakai H, Ishikawa F, Shibanuma M : Linkage of E2F1 transcriptional network and cell proliferation with respiratory chain activity in breast cancer cells. Cancer Sci., 107: 963-971, 2016（査読有）

Arai T, Ohno A, Mori K, Kakizawa T, Kuwata H, Ozawa T, Shibanuma M, Hara S, Ishida S, Kurihara M, Miyata N, Nakagawa H, Fukuhara K: Design, synthesis, and evaluation of Trolox-conjugated amyloid-β C-terminal peptides for therapeutic intervention in an in vitro model of Alzheimer's disease. Bioorg Med Chem., 24: 4138-4143, 2016（査読有）

Nawata S, Kohyama N, Uchida N, Numazawa S, Ohbayashi M, Kobayashi Y, Iwata M, Nakajima T, Saito H, Izuka A, Yamamoto T. The pharmacokinetics of mianserin suppositories for rectal administration in dogs and healthy volunteers: a pilot study. J Pharm Health Care Sci. 2:12, 2016 (査読有)

*Ashino T, Yamamoto M, Numazawa S. Nrf2/Keap1 system regulates vascular smooth muscle cell apoptosis for vascular homeostasis: role in neointimal formation after vascular injury. Sci Rep, 6:26291, 2016 (査読有)

Kanemaru Y, Suzuki T, Sassa A, Matsumoto K, Adachi N, Honma M, Numazawa S, Nohmi T. DNA polymerase kappa protects human cells against MMC-induced genotoxicity through error-free translesion DNA synthesis. Genes Environ. 39:6, 2017 (査読有)

シグナル制御班:

*Kim Y, Lim S, Ha T, Song YH, Sohn YI, Park DJ, Paik SS, Kim-Kaneyama JR, Song MR, Leung A, Levine EM, Kim IB, Goo YS, Lee SH, Kang KH, Kim JW. : The LIM protein complex establishes a retinal circuitry of visual adaptation by regulating Pax6 α-enhancer activity. Elife, 6. pii: e21303, 2017 (査読有)

Nishimoto S, Fukuda D, Higashikuni Y, Tanaka K, Hirata Y, Murata C, Kim-Kaneyama JR, Sato F, Bando M, Yagi S, Soeki T, Hayashi T, Imoto I, Sakaue H, Shimabukuro M, Sata M. : Obesity-induced DNA released from adipocytes stimulates chronic adipose tissue inflammation and insulin resistance. Sci Adv. 2(3):e1501332. 2016 (査読有)

Shimabukuro M, Okawa C, Yamada H, Yanagi S, Uematsu E, Sugasawa N, Kurobe H, Hirata Y, Kim-Kaneyama JR, Lei XF, Takao S, Tanaka Y, Fukuda D, Yagi S, Soeki T, Kitagawa T, Masuzaki H, Sato M, Sata M. : The pathophysiological role of oxidized cholesterols in epicardial fat accumulation and cardiac dysfunction: A study in swine fed a high caloric diet with an inhibitor of intestinal cholesterol absorption, ezetimibe. J Nutr Biochem. 35:66-73, 2016 (査読有)

*Petropoulos C, Oddou C, Emadali A, Hiriart-Bryant E, Faurobert E, Vande Pol S, Kim-Kaneyama JR, Kraut A, Coute Y, Block M, Albiges-Rizo C, Destaing O. : Roles of paxillin family members in adhesion and ECM degradation coupling at invadosomes. J Cell Biol. 213(5):585-99. 2016 (査読有)

Miyazaki T, Tonami K, Hata S, Aiuchi T, Ohnishi K, Lei XF, Kim-Kaneyama JR, Takeya M, Itabe H,
Sorimachi H, Kurihara H, Miyazaki A. : Calpain-6 confers atherogenicity to macrophages by dysregulating
pre-mRNA splicing. J Clin Invest. 126(9):3417-32, 2016 (査読有)

Chang SH, Yasui T, Taketomi S, Matsumoto T, Kim-Kaneyama JR, Omiya T, Hosaka Y, Inui H, Omata Y, Yamagami R, Mori D, Yano F, Chung U, Tanaka S, Saito T. : Osteoarthritis Cartilage. 24(4):688-97, 2016 (査読有)

*Lei XF, Fu W, Kim-Kaneyama JR⁑, Omoto T, Miyazaki T, Li B, Miyazaki A. : Hic-5 deficiency attenuates the activation of hepatic stellate cells and liver fibrosis through upregulation of Smad7 in mice. J Hepatol. 64(1):110-7, 2016 (査読有)

Okabe T, Ogura T, Yoshimura T, Tanaka Y, Toyoda H, Fujita K, Sasaki Y: Bioequivalence studies of a generic formulation (SW651K) to the brand drug S-1 in tumor-bearing rat models. J. Bioequiv. Availab., 8: 112-117, 2016 (査読有).

Matsunaga M, Kaneta T, Miwa K, Ichikawa W, Fujita K, Nagashima F, Furuse J, Kage M, Akagi Y, Sasaki Y: A comparison of four methods for detecting KRAS mutations in formalin-fixed specimens from metastatic colorectal cancer patients. Oncol Lett., 12: 150-156, 2016 (査読有).

Saito K, Inoue Y, Ikegami Y, Nanbo I, Onozuka M, Sano K, Yoshida H, Sakamoto T, Tatebayashi E, Fujita K, Sasaki Y, KitazawaT: Investigation of bioequivalence between brand-name and generic irinotecan products. Anticancer Res., 39: 5957-5964, 2016 (査読有).

Takata K, Fujita K, Kubota Y, Ishida H, Ichikawa W, Shimada K, Sekikawa T, Taki-Takemoto I, Kamei D, Iwai S, Sasaki Y: Cost-minimization analysis of adjuvant chemotherapy regimens given to patients with colorectal cancer in Japan. J. Pharm. Health Care Sci., Epub ahead of print, 2016 (査読有).

Ishikawa H, Fukui T, Ino S, Sasaki H, Awano N, Kohda C, Tanaka K: Influenza virus infection causes neutrophil dysfunction through reduced G-CSF production and an increased risk of secondary bacteria infection in the lung. Virology, 499 : 23-29, 2016(査読有)

Ino S, Kohda C, Takeshima K, Ishikawa H, Norose T, Yamochi T, Takimoto M, Takahashi H, Tanaka K.: Oral tolerance is inducible during active dextran sulfate sodium-induced colitis. World J Gastrointest Pharmacol Ther,7:242-53, 2016(査読有)

Ishikawa H, Ino S, Sasaki H, Fukui T, Kohda C, Tanaka K.: The protective effects of intranasal administration of IL-12 given before influenza virus infection and the negative effects of IL-12 treatment given after viral infection. J Med Virol,88:1487-96.2016(査読有)

*Ahmed KM, Zhang T, Ono K, Tsutsuki H, Ida T, Akashi S, Miyata K, Oike Y, Akaike T, Sawa T: Synthesis and characterization of 8-nitroguanosine 3’,5’-cyclic monophosphorothioate Rb-isomer as a potent inhibitor of protein kinase G1α. Biol Pharm Bull, 40:365-374, 2017 (査読有)

*Abiko Y, Sha L, Shinkai Y, Unoki T, Luong NC, Tsuchiya Y, Watanabe Y, Hirose R, Akaike T, Kumagai Y: 1,4-Naphthoquinone activates the HSP90/HSF1 pathway through the S-arylation of HSP90 in A431 cells: Negative regulation of the redox signal transduction pathway by persulfides/polysulfides. Free Rad Biol Med, 104:118-128, 2017 (査読有)

*Kunikita H, Ida T, Sato K, Aizawa N, Sawa T, Tawarayama H, Murayama N, Fujii S, Akaike T, Nakazawa T: Metabolomic profiling of reactive persulfides and polysulfides in the queous and vitreous humors. Sci Rep, 7:41984, 2017 (査読有)

*Jung M, Kasamatsu S, Matsunaga T, Akashi S, Ono K, Nishimura A, Morita M, Adbdul Harmid H, Fujii S, Kitamura H, Sawa T, Ida T, Motohashi H, Akaike T: Protein polysulfidation-dependent persulfide dioxygenase activity of ethylmalonic encephalopathy protein 1. Biochem Biophys Res Commun, 480:180-186, 2016 (査読有)

*Yoshitake J, Soeda Y, Ida T, Sumioka A, Yoshikawa M, Matsushita K, Akaike T, Takashima A: Modificationof Tau by 8-nitroguanosine 3’,5’-cyclic monophosphate (8-nitro-cGMP): Effects of nitric oxide-linked chemical modification on Tau aggregation. J Biol Chem, 291:22714-22720, 2016 (査読有)

*Tsutsuki H, Jung M, Zhang T, Ono K, Ida T, Kunirda K, Ihara H, Akaike T, Sawa T: Endogenous occurrence of protein S-guanylation in Escherichia coli: Target identification and genetic regulation. Biochem Biophys Res Commun, 478:7-11, 2016 (査読有)

*Yugami M, Odagiri H, Endo M, Tsutsuki H, Fujii S, Kadomatsu T, Masuda T, Miyata K, Terada K, Tanoue H, Ito H, Morinaga J, Horiguchi H, Sugizaki T, Akaike T, Gotoh T, Takai T, Sawa T, Mizuta H, Oike Y: Mice deficient in angiopoietin-like protein 2 (Angptl2) gene show increased susceptibility to bacterial infection due to attenuated macrophage activity. J Biol Chem, 91:18843-18852, 2016 (査読有)

Kawamura Y, Tomida J, Miyoshi-Akiyama T, Okamoto T, Naeita M, Hashimoto K, Cnockaert M, Vandamme P, Morita Y, Sawa T, Akaike T: Proposal of Helicobactoer canicola sp. Nov., previously identified as Helicobacter cinaedi isolated from canines. Syst Appl Microbiol, 39:307-312, 2016 (査読有)

診断･検査班:

*Kadena M, Kumagai Y, Vandenbon A, Matsushima H, Fukamachi H, Maruta N, Kataoka H, Arimoto T, Morisaki H, Funatsu T, Kuwata H. : Microarray and gene co-expression analysis reveals that melatonin attenuates immune responses and modulates actin rearrangement in macrophages. Biochem Biophys Res Commun. Epub 2017 Feb 13. 485(2):414-420. (査読有)

*Matsushima H, Kumagai Y, Vandenbon A, Kataoka H, Kadena M, Fukamachi H, Arimoto T, Morisaki H, Fujiwara N, Okahashi N, Kuwata H. : Microarray analysis of macrophage response to infection with Streptococcus oralis reveals the immunosuppressive effect of hydrogen peroxide. : Biochem Biophys Res Commun. Epub 2017 Feb 13. ;485(2):461-467. (査読有)

*Okahashi N, Nakata M, Kuwata H, Kawabata S. : Streptococcus oralis Induces Lysosomal Impairment of Macrophages via Bacterial Hydrogen Peroxide. Infect Immun. 2016 Jun 23;84(7):2042-50. (査読有)

Potential effect of cationic liposomes on interactions with oral bacterial cells and biofilms.
Sugano M, Morisaki H, Negishi Y, Endo-Takahashi Y, Kuwata H, Miyazaki T, Yamamoto M.
J Liposome Res. 2016;26(2):156-62. (査読有)

Kamono A, Kato M, Ogihara N; Accuracy evaluation of a method to partition ground reaction force and center of pressure in cane-assisted gait using an instrumented cane with a triaxial force sensor, Medical Engineering & Physics, 2017年1月24日投稿中(査読有)

秋山徹雄, 関屋曻, 中村大介, 加茂野有徳; 正常歩行における下腿座標系上の円弧状圧中心軌跡, 理学療法学, 43(6), 445-452, 2016(査読有)
Toyokuni S. : The origin and future of oxidative stress pathology: From the recognition of carcinogenesis as an iron addiction with ferroptosis-resistance to non-thermal plasma therapy. Pathol Int, 66: 245-259, 2016. (査読有)
Toyokuni S. : Oxidative stress as an iceberg in carcinogenesis and cancer biology. Arch Biochem Biophys, 595:46-49, 2016. (査読有)

Ito F, Nishiyama T, Shi L, Mori M, Hirayama T, Nagasawa H, Yasui H and Toyokuni S. : Contrasting intra- and extracellular distribution of catalytic ferrous iron in ovalbumin-induced peritonitis. Biochem Biophys Res Commun, 476: 600-606, 2016. (査読有)

Chew SH, Okazaki Y, Akatsuka S, Wang S, Jiang L, Ohara Y, Ito F, Saya H, Sekido Y, Toyokuni S. : Rheostatic CD44 isoform expression and its association with oxidative stress in human malignant mesothelioma. Free Radic Biol Med 106:91-99, 2017. (査読有)

治療･回復班:

*Sasai M, Iso Y, Mizukami T, Tomosugi N, Sambe T, Miyazaki A, Suzuki H. Potential contribution of the hepcidin-macrophage axis to plaque vulnerability in acute myocardial infarction in human. Int J Cardiol. 2017;227:114-121.（査読あり）

*Suzuki H, Maeda A, Maezawa H, Togo T, Nemoto H, Kasai Y, Ito Y, Nakada T, Sueki H, Mizukami A, Takayasu M, Iwaku K, Takeuchi S, Tanaka H, Iso Y. The efficacy of a multidisciplinary team approach in critical limb ischemia. Heart Vessels. 2017;32:55-60.（査読あり）

*Maezawa H, Maeda A, Iso Y, Sakai T, Suzuki H. The histological characteristics and virtual histology findings of the tissues obtained by a distal protection device during endovascular therapy for peripheral artery disease. J Cardiol. 2017;69:125-130.（査読あり）

*Mizukami T, Iso Y, Sato C, Sasai M, Spees J, Toyoda M, Umezawa A, Miyazaki A, Suzuki H. Priming with Erythropoietin Enhances Cell Survival and Angiogenic Effect of Mesenchymal Stem Cell Implantation in Rat Limb Ischemia. Regenerative Therapy 2016;4:1-8.（査読あり）

*Mori H, Maeda A, Wakabayashi K, Sato T, Sasai M, Tashiro K, Iso Y, Ebato M, Suzuki H. The Effect of Cilostazol on Endothelial Function as Assessed by Flow-Mediated Dilation in Patients with Coronary Artery Disease. J Atheroscler Thromb. 2016;23:1168-1177.（査読あり）

Naito C, Hashimoto M, Watanabe K, Shirai R, Takahashi Y, Kojima M, Watanabe R, Sato K, Iso Y, Matsuyama TA, Suzuki H, Ishibashi-Ueda H, Watanabe T. Facilitatory effects of fetuin-A on atherosclerosis. Atherosclerosis 2016;246:344-351.（査読あり）

Watanabe R, Watanabe H, Takahashi Y, Kojima M, Konii H, Watanabe K, Shirai R, Sato K, Matsuyama T, MD, Ishibashi-Ueda H, Iso Y, Koba S, Kobayashi Y, Hirano T, Watanabe T. Atheroprotective Effects of Tumor Necrosis Factor–Stimulated Gene-6. J Am Coll Cardiol Basic Trans Science. 2016;1:494–509. （査読あり）

予防･維持班:

*安部聡子，下司映一，原雅文：健診受診者におけるHbA1C非コントロール群に関する検討．日本未病システム学会雑誌vol22(1)，34-38，2016（査読有）

*安部聡子，原雅文，大中佳子，下司映一：女性健診受診者の年代別朝食欠食とメタボリックシンドローム関連指標による検討．人間ドックvol.31(4)，570-579，2016（査読有）

作田浩行：失敗なし学習と能動的活動が認知症者に与える影響について－評価指標の定量化および介入プログラムの開発と効果の検証－. 吉備国際大学学術機関リポジトリ, online, 2016 (学位論文)

古賀誠,横道洋司,丹羽正利,山縣然太朗:重心動揺計を用いて測定した統合失調症患者の重心動揺とその関連要因の検討,日本保健科学学会誌19(1):24-32,2016.（査読有）

総説（国内、国際）

分子･遺伝子同定班:

Umeno A, Horie M, Murotomi K, Nakajima Y, Yoshida Y. Antioxidative and Antidiabetic Effects of Natural Polyphenols and Isoflavones. Molecules. 30, 21, pii: E708, 2016.

細胞機能制御班:

Suzawa T, Yoshida H, Itose M, Takimoto R, Saito E, Suzuki D, Inagaki K, Shirota T, Maki K, Kamijo R: Neural crest-derived cells in the oral and maxillofacial regions of adult mice: isolation and application for regenerative medicine. Showa Univ J Med, 28(3):209-217, 2016

吉村健太郎，須澤徹夫，鈴木 大，上條竜太郎：カルシウム代謝から見る口腔インプラント．日本口腔インプラント学会誌，29(1):4-11, 2016

鈴木 大，齋藤愛美，馬目遥子，上條竜太郎：口腔におけるカルシウム制御とアンチエイジング．Importance of calcium metabolism for oral health and anti-aging strategies. アンチ・エイジング医学，12(2):41-46, 2016

Shibanuma M, Mori K, Ishikawa F: Intracellular redox and mitochondria regulation by transforming growth factor-β―its implication in induction of epithelial-mesenchymal transition. J. Cell Signaling, doi:10,4172/JCS.1000106, 2016

シグナル制御班:

Kigawa Y, Miyazaki T, Lei XF, Kim-Kaneyama JR, Miyazaki A. Functional heterogeneity of NADPH oxidases in atherosclerotic and aneurysmal diseases. J Atheroscler Thromb. 24(1):1-13, 2017 (査読有)

藤田健一：併存疾患を有する高齢がん患者への対応-polypharmacy．Cancer Board Square, 2: 64-68, 2016 (査読無).

中島美紀，藤田健一，佐々木康綱：日本人におけるmicroRNA-SNP 解析：分子標的薬の個別化療法最適化に向けて．臨床薬理の進歩(Recent advances in clinical pharmacology), in press, 2016 (査読無).

Fujita K, Ishida H, Kubota Y, Sasaki Y: Toxicities of receptor tyrosine kinase inhibitors in cancer pharmacotherapy: management with clinical pharmacology. Curr. Drug Metab., Epub ahead of print, 2017 (査読有).

*笠松真吾，守田匡伸，赤池孝章：レドックスシグナルの活性イオウ分子制御．ファルマシア, 53:210-214, 2017

*Kasamatsu S, Nishimura A, Morita M, Matsunaga T, Ab dul Hamid H, Akaike T: Redox signaling regulated by cysteine persulfide and protein polysulfidation. Molecules 21:1721, 2016

*Millikin R, Blanco CL, White C, Saund SS, Henriquez S, Sosa V, Akaike T, Kumagai Y, Soeda S, Toscano JP, Lin J, Fukuto JM: The chemical biology of protein hudropersulfides: Studies of a possible protective function of biological hydropersulfide generation. Free Radic Biol Med, 97:136-147, 2016

*Fujii S, Sawa T, Nishida M, Ihara H, Ida T, Motohashi H, Akaike T: Redox signaling regulated by electrophoilic cyclic nucleotide and reactive cysteine persulfides. Arch Biochem Biophys, 595:140-1406, 2016

*笠松真吾，藤井重元，赤池孝章：酸化ストレスシグナルと8-ニトロ-cGMPによる感染防御機構．医学のあゆみ 「マクロファージのすべて」, 147:278-284, 2016

*井田智章，松永哲郎，藤井重元，澤 智裕，赤池孝章：活性イオウ含有分子の再発見とその生物活性. 薬理学会誌, 147:278-284, 2016

*笠松真吾，藤井重元，赤池孝章：活性イオウ分子種によるタンパク質チオール修飾．ポリスルフィド化タンパク質解析の最先端技法．薬理学会誌, 147:299-302, 2016

治療･回復班:

*礒　良崇、野木彩香．末梢動脈疾患の予防に向けた病態解明．心臓リハビリテーション（JJCR）．22:136-141.2016

*礒　良崇、北井仁美．心肺運動負荷試験による心疾患のコンディション評価．バイオメカニクス研究．20:93-99.2016

田代尚範：ICUでの早期リハビリテーションにおける理学療法士の役割について：日本集中治療医学会編．集中治療室における早期リハビリテーション　根拠に基づくエキスパートコンセンサス，38－39，医歯薬出版，2017

宇野真理子、田代尚範：心臓リハビリテーション：森山美知子、木原康樹、宇野真理子、中麻規子編．エビデンスに基づく循環器看護ケア関連図，332－341，中央法規出版，2017

田代尚範：補助換気療法：國原孝編．ハートチームのための心臓血管外科手術周術期管理のすべて，162－167，メジカルビュー社，2017

田代尚範：【7人の職種が選ぶ!　心不全　最新キーワード30】 理学療法士が選ぶ!最新キーワード4，ハートナーシング，29（9），867-872，2016

著書（国内、国際）

細胞機能制御班:

上條竜太郎：リサーチマインド教育．日本歯科医学教育学会誌別冊 歯科医学教育白書 (2016). 日本歯科医学教育学会，49-54
予防･維持班:

井廻道夫，菅原スミ編，安部聡子他著：新体系 看護学全書 ．専門分野Ⅱ成人看護学　消化器，メヂカルフレンド社．425-430，532-540，2016

石井良和,京極 真,長雄眞一郎・編:クリニカル作業療法シリーズ　精神領域の作業療法第2版: pp.214-221,中央法規,東京,2016.

治療･回復班:

*Kitai H, Kyuno K, Nogi A, Maezawa H, Ebato M, Sambe T, Suzuki H, Iso Y. Therapeutic impact of cardiac rehabilitation exercise on cardiac Fabry woman treated with enzyme replacement therapy. Int J Cardiol Metabolic and Endocrine. 2016;13:23-25

予防･維持班:

古賀 誠,石井良和,長雄眞一郎:統合失調症クライエントのセルフスティグマに焦点を当てた作業療法介入,作業行動研究20(2):84-93,2016. （査読有）



学会発表したもののうち、受賞した発表（国内学会、国際学会）

分子･遺伝子同定班:

福原　潔 : ニトロアレーン類とポリフェノール類の変異誘発機序の有機化学的アプローチによる解明と医薬品化学への応用.日本環境変異原学会第45回大会, つくば, 2016年11月18日, 望月喜多司記念賞受賞

細胞機能制御班:

*金子児太郎，星野真理江，宮本洋一，宇山理沙，近津大地，上條竜太郎：新規内因性シグナル分子8-ニトロ-cGMPは骨の伸長を促進する．第53回日本口腔組織培養学会学術大会，金沢，2016年11月18日，ベストプレゼンテーション賞受賞

馬目遥子，望月文子，高見正道，上條竜太郎：TLRリガンドのR848は悪性黒色腫の骨浸潤を抑制する．第53回日本口腔組織培養学会学術大会，金沢，2016年11月18日，ベストプレゼンテーション賞受賞

泉田恵理，宮本洋一，山口徹太郎，須澤徹夫，上條竜太郎，槇 宏太郎：疾患特異的iPS細胞を用いた原発性放出不全発症機序の解析．第75回日本矯正歯科学会大会，徳島，2016年11月7-9日，優秀発表賞受賞

シグナル制御班:

*井田智章，魏 范研，松永哲郎，西田基宏，澤 智裕，西村明幸，守田匡伸，笠松真吾，居原 秀，藤井重元，熊谷嘉人，本橋ほづみ，赤池孝章：新しいシステインパースルフィド合成酵素の発見とパースルフィドによるミトコンドリア機能制御機構の解明．第69回日本酸化ストレス学会学術集会，仙台，2016年8月30，31日，学術奨励賞

*守田匡伸，井田智章，松永哲郎，笠松真吾，藤井重元，赤池孝章：ヒトCARS2 KO細胞株を用いたタンパク質ポリサルファ化およびミトコンドリア生合成におけるCARS2の機能解析．第69回日本酸化ストレス学会学術集会，仙台，2016年8月30，31日， 優秀ポスター賞

*Hisyan bin Abdul Hamid，井田智章，笠松真吾，居原 秀，土屋幸弘，渡邊泰男，澤 智裕，藤井重元，赤池孝章：活性イオウ分子種の新規検出法の開発．第69回日本酸化ストレス学会学術集会，仙台，2016年8月30，31日， 優秀ポスター賞

診断･検査班:

*岡橋暢夫、中田匡宣、桑田啓貴、川端重忠：Streptococcus oralis由来の過酸化水素はマクロファージのリソソームを傷害する。第５８回歯科基礎医学会学術大会、北海道札幌市、2016年8月24-26日

*嘉手納未季、桑田啓貴：メラトニンによる自然免疫系を介した炎症調節機構の解明
第2回日本骨免疫学会 ホテルモントレ沖縄、沖縄県国頭郡 2016年7月6-8日

*松島瞳、片岡嗣雄、岡橋暢夫、熊谷雄太郎、井上美津子、桑田啓貴：Streptococcus oralis 産生過酸化水素によるマクロファージの炎症性遺伝子発現制御について：Streptococcus oralis 産生過酸化水素によるマクロファージの炎症性遺伝子発現制御について。第90回細菌学会総会 - 仙台国際センター, 宮城県仙台市 2017年3月19-21日

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