最近の研究報告（2015-2024）　　

英文原著論文・総説

2024年

1. Ohinata H, Phimarn W, Mizuno M, Obama T, Fukuhara K, Makiyama T, Watanabe Y, Itabe H. Supressive effect of resveratrol, catwechin and their confomationally constrained analogs on neutrophil extracellular trap formation by HL-60-derived neutrophils. J Clin Biol. Med. 2024, 75: 17-23.

2. Watanabe Y, Obama T, Makauiyama T, Itabe H. Oxysterols suppress release of DNA from granurocytes into extraceellular space after stimulation with phorbol myristate acetate. Biomedicines, 2024, 12:2535.


2023年

1. Makiyama T, Obama T, Watanabe Y, Chatani M, Azetsu Y, Kawaguchi K, Imanaka T, Itabe H. Behavior of intracellular lipid droplets during cell division in HuH7 hepatoma cells, Exp. Cell Res. 2023, 433:113855. doi: 10.1016/j.yexcr.2023.113855

2. Yamamoto M, Sugano M, Itabe H. The etiological consideration of oxidized low-density lipoprotein in periodontitis. J Oral Biosci. . doi: 1031016/j.job.2022.09.006.

3. Itabe H, Obama T. The oxidized lipoproteins in vio: Its diversity and behavior in the human circulation. Int J Mol Sci. 2023, 24:5747. doi: 10.3390/ijms24065747.


2022年

1. Makiyama T, Obama , Watanabe Y, Itabe H.: Sar1 affects the localization of perilipin2 to lipid droplets. Int. J. Mol. Sci. 2022, 23: 6366. doi.10.3390/ijms23126366

2. Ohinata H, Obama T, Makiyama T, Watanabe Y, Itabe H. High-density lipoprotein suppresses neutrophil extracellular traps enhanced by oxidized low-density lipoprotein or oxidized phospholipids. Int J Mol Sci 2022, 23: 13992. doi: 10.3390/ijms232213992..


2021年

1. Itabe H, Sawada N, Makiyama T, Obama T.: Structure and dynamics of oxidized lipoproteins in vivo: roles of high-density lipoprotein. Biomedicines. 2021, 9: 655. doi.org/10.3390/biomedicines9060655

2. Phimarn W, Bunleu S, Itabe H.: Effects of triphala toimprove lipid profile and blood glucose and anthropometric parameters. J. Evidence-Based Integr. Med. 2021, 26. doi.org/10.1177/2515690X211011038.

3. Kato S, Osuka Y, Khalifa S, Obama T, Itabe H, Nakagawa K.: Investigation of lipoproteins oxidation mechanisms by the analysis of lipid hydroperoxide isomers. Antioxidants, 2021, 10:1598


2020年

1. Odanaka H, Obama T, Sawada N, Sugano M, Itabe H, Yamamto M.: Comparison of protein profiles of the pellicle, gingival crevicular fluid, and saliva: possible origin of pellicle proteins. Biol. Res. 2020, 53:3.

2. Sawada N, Obama T, Koba S, Takaki T, Iwamoto S, Aiuchi T, Kato R, Kikuchi M, Hamazaki Y, Itabe H.: Circulating oxidized LDL increased in patients with acute myocardial infarction is accompanied by heavily modified HDL. J. Lipid Res. 2020, 61:816-829.

3. Sawada N, Obama T, Mizuno M, Fukuhara K, Iwamoto S, Aiuchi T, Makiyama T, Itabe H.: Transfer and enzyme-mediated metabolism of oxidized phosphatidylcholine and lysophosphatidylcholine between low- and hihg-density lipoproteins. Antioxidants, 2020, 9:E1045.

4. Shimamura H, Katsuragi S, Yoshikawa M, Nakura M, Sasaki T, Itabe H.: Standard pharmacist intervention checklist to improve the appropriateness use of medications for inpatients with polypharmacy. BPB Rep. 2020, 3:196-201.


2019年

1. Kato R, Hayashi M, Aiuchi T, Sawada N, Obama T, Itabe H.: Temporal and spatial changes of peroxiredoxin 2 levels in aortic media at very early stages of atheroslcerotic lesion formation in apE-knockout mice. Free Rad. Biol. Med. 2019, 130:348-360.

2. Itabe H, Kato R, Sasabe S, Obama T, Yamamoto M.: Significance of oxidized low-density lipoprotein in body fluids as a marker related to diseased conditions. Curr. Med. Chem. 2019, vol.26: 1576-1593. (review)

3. Obama T, Miyazaki T, Aiuchi T, Miyazaki A, Itabe H.: Evaluation pf protein-protein interactions using an on-membrane digestion technique. JoVE, 2019, 149:e59733.

4. Obama T, Ohinata H, Takaki T, Iwamoto S, Sawada N, Aiuchi T, Kato R, Itabe H.: Cooperative action of oxidized low-density lipoproteins and neutrophils on endothelial inflammatory responses through neutrophil extracellular trap formation. Frontiers in Immunology, 2019, 10:1899.

5. Kawata N. Kang D, Aiuchi T, Obama T, Shibata T, Murakami M, Takimoto M, Itabe H, Honda K. Proteomics of human glomerulonephritis by laser microdisection and liquid-chromatography-tandem mass spectrometry. Nephrology, 2019, 25:351-359.

6. Uekita H, Ishibashi T, Shiomi M, Koyama H, Ohtsuka S, Yamamoto H, Yamagishi S, Inoue H, Itabe H, Sugimoto K, Kamioka M, Ohkawara H, Wada I, Yasuchika T.: Integral role of receptor for advanced glycation end products (RAGE) in nondiabetic atherosclerosis. Fukushima J. Med. Sci. 2019, 65:109-121.

7. Takemaru M, Sawada N, Aiuchi T, Itabe H, Yamamoto M.: Comparison of protei profiles of gingival crevicular fluids collected from incisiors, canines and molars. Showa Univ. J. Med. Sci. 2019, 31:365-372.


2018年

1. Kuwata H, Yuzurihara C, Kinoshita N, Taki Y, Ikegami Y, Washio S, Hirakawa Y, Yoda E, Aiuchi T, Itabe H, Nakatani Y, Hara S.: The group VIA calcium-independent phospholipase A2 and NFATc4 pathway mediates IL-1β-induced expression of chemokines CCL2 and CXCL10 in rat fibroblasts. FEBS J. 2018;285(11):2056-2070.

2. Shimamura H, Yamada H, Okada N, Uchikura T, Tanaka K, Sasaki T, Itabe H.: A standard intervention practice to promote appropriate lamotrigine therapy by pharmacists. Biol. Pharm. Bull. 2018, 41(4) 465-469.

3. Ning B, Chen Y, Waqar AB, Yan H, Shiomi M, Zhang J, Chen YE, Wang Y, Itabe H, Liang J, Fan J.: Hypertension enhances advanced atherosclerosis and induces cardiac death in Watanabe heritable hyperlipidemic rabbits. Am. J. Pathol. 2018, 188(12):2936-2947.


2017年

1. Ishizuka M, Kato R, Moriya Y, Noguchi E, Koide Y, Inoue S, Itabe H, Yamamoto M.: Changes in apolipoprotein B and oxidized low-density lipoprotein levels in gingival crevicular fluids caused by periodontal tissue conditions. J. Periodont. Res. 2017, 52:594-602.

2. Moriya Y, Obama T, Aiuchi T, Sugiyama T, Endo Y, Koide Y, Noguchi E, Ishizuka M, Inoue M, Itabe H, Yamamoto M.: Quantitative proteomic analysis of gingival crevicular fluids from deciduous and permanent teeth. J. Clin. Periodontol. 2017, 44:353-362.

3. Yamada S, Koike T, Nakagawa T, Kuniyoshi N, Ying Y, Itabe H, Yamashita A, Asada Y, Shiomi M.: Morphological features of coronary plaques in WHHLMI rabbits (Oryctolagus cuniculus), An animal model for familial hypercholesterolemia. Experimental Animals, 2017, 66:145-157.

4. Forrester SJ, Elliott KJ, Kawai T, Obama T, Boyer MJ, Preston KJ, Yan Z, Eguchi S, Rizzo V.: Caveolin-1 Deletion Prevents Hypertensive Vascular Remodeling Induced by Angiotensin II. Hypertension. 2017, 69:79-86.

5. Itabe　H, Yamaguchi T, Nimura S, asabe N.: Perilipins: A diversity of intracellular lipid droplet proteins. Lipids Health Dis. 2017, 16:83. (review)


2016年

1. Kurosawa T, Yamada A, Suzuki D, Morimura N, Sasagane Y, Itabe H, Kamijo R. Nephronectin expression is up-regulated by BMP-2. Biol. Pharm. Bull., 2016, 39:1211-1215. doi: 10.1248/bpb.b15-00941.

2. Miyazaki T, Tonami K, Hata S, Aiuchi T, Ohnishi K, Lei X-F, Kim-Kaneyama J, Takeya M, Itabe, H, Sorimachi H, Kurihara H, Miyazaki A.: Disturbance of pre-mRNA splicing by calpain-6 aggravates pinocytotic cholesterol deposition in macrophages. J. Clin. Invest. 2016, 126:3417-3432. doi: 10.1172/JCI85880.


2015年

1. Arita-Okubo S, Kim-Kaneyama JR, Lei XF, Fu WG, Ohnishi K, Takeya M, Miyauchi A, Honda H, Itabe H, Miyazaki T, Miyazaki A.: Role of Hic-5 in the formation of microvilli-like structures and the monocyte-endothelial interaction that accelerates atherosclerosis. Cardiovasc. Res. 2015, 105:361-371. doi: 10.1093/cvr/cvv003.

2.Tamaki Kurosawa, Atsushi Yamada, Masamichi Takami,Dai Suzuki, Yoshiro Saito, Katsuhiro Hiranuma, Takuya Enomoto, Naoko Morimura, Matsuo Yamamoto, Takehiko Iijima, Tatsuo Shirota, Hiroyuki Itabe, Ryutaro Kamijo. Expression of Nephronectin is inhibited by Oncostatin M via both JAK/STAT and MAPK pathways. FEBS Open Bio. 2015, 5:303-307. doi10.1016/j.fob.2015.04.001.

3.Yuka Keyamura, Chifumi Nagano, Masayuki Kohashi, Manabu Niimi, Masanori Nozako, Takashi Koyama, Hiroyuki Itabe, Tomohiro Yoshikawa.: Dietary-cholesterol atherogenesis drastically changed during the juvenile period in rabbits. Biol. Pharm. Bull. 2015, 38:785-788..doi. 10.1016/j.fob.2015.04.001.

4. Takayanagi T, Kawai T, Forrester SJ, Obama T, Tsuji T, Fukuda Y, Elliott KJ, Tilley DG, Davisson RL, Park JY, Eguchi S. Role of Epidermal Growth Factor Receptor and Endoplasmic Reticulum Stress in Vascular Remodeling Induced by Angiotensin II. Hypertension. 2015 65:1349-1355. doi: 10.1161/HYPERTENSIONAHA.115.05344.

5. Obama T, Tsuji T, Kobayashi T, Fukuda Y, Takayanagi T, Taro Y, Kawai T, Forrester SJ, Elliott KJ, Choi E, Daugherty A, Rizzo V, Eguchi S. Epidermal growth factor receptor inhibitor protects against abdominal aortic aneurysm in a mouse model. Clin Sci (Lond). 2015, 128:559-565. doi: 10.1042/CS20140696.

6. Tomohiro Yamaguchi, Noriyuki Fujikawa, Satomi Nimura, Yutaro Tokuoka, Sonoka Tsuda, Toshihiro Aiuchi, Rina Kato, Takashi Obama, Hiroyuki Itabe. Characterization of lipid droplets in steroidogenic MLTC-1 Leydig cells: Protein profiles and the morphological change induced by hormone stimulation. BBA - Molecular and Cell Biology of Lipids, 2015, 1851:1285-1295. doi:10.1016/j.bbalip.2015.06.007.

7.Satomi Nimura, Tomohiro Yamaguchi, Koki Ueda, Karin Kadokura, Toshihiro Aiuchi, Rina Kato, Takashi Obama, Hiroyuki Itabe. Olanzapine promotes the accumulation of lipid droplets and the expression of multiple perilipins in human adipocytes. Biochem. Biophys. Res. Commun. 2015, 467: 906-912. doi:10.1016/j.bbrc.2015.10.045

和文総説・著書

１．　小濱孝士、板部洋之：　血管炎症誘導における酸化変性リポタンパク質と好中球細胞外トラップ形成の相乗作用　（特集　動脈硬化とNETs）　MSD メディカル・サイエンス・ダイジェスト　（2022）　48：300-302

2．　板部洋之：　動脈硬化の発症・進展に関わる酸化変性リポタンパク質　昭和大学学士会雑誌　（2021）
　　　81：370-9　

３．　板部洋之、小濵孝士ら：「詳解　生化学」（板部、荒田　編著）　京都廣川書店　（2021）

４．　小濵孝士、板部洋之：　動脈硬化とNETｓ：酸化LDLとの相乗作用　Thrombosis Medicine　（2019）　9：285-291

５．　笹部直子、板部洋之:　Lp-PLA2と変性リポタンパク質の代謝　臨床化学　(2018) 7巻2号128-135

６.　 板部洋之ら：構造式手帳第2版　（伊藤喬編著）（2016）　京都廣川書店、東京

７.「生物系薬学Ⅱ．生体防御と微生物」（スタンダード薬学シリーズⅡ４、高橋悟、野口雅久、山元弘、板部洋之、有賀寛芳、奥直人　編）　（2016）　東京化学同人、東京

８.　小浜孝士、板部洋之：　生体内酸化LDL中のバイオマーカー網羅的探索　昭和学士会雑誌（2015）75:138-146

９.「カラー生化学　第4版」 マシューズ、ヴァン・ホルダ、アプリング、アンソニー・ケイヒル
（石浦章一、板部洋之、高木正道、中谷一泰、水島昇、横溝岳彦　監訳）（2015） 西村書店、東京